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Keywords: LPS
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Journal Articles
J Cell Sci (2018) 131 (1): jcs207605.
Published: 10 January 2018
... recovery from LPS-induced barrier disruption in vivo . However, only Rap1A deficiency increased permeability in ECs and lung vessels. Interestingly, Rap1B deficiency attenuated VEGF-induced permeability in vivo and AJ remodeling in vitro . Therefore, only Rap1A is required for the maintenance of normal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (11): 2143–2155.
Published: 01 June 2015
..., we demonstrate that in murine macrophages, low-dose NFκB inhibitors specifically attenuates lipopolysaccharide (LPS)-induced IκBβ degradation and the expression of a select subset of target genes (encoding IL1β, IL6, IL12β). Gain- and loss-of-function experiments demonstrate the necessary and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (10): 1982–1990.
Published: 15 May 2015
...Deepthi Menon; Rebecca Coll; Luke A. J. O'Neill; Philip G. Board ABSTRACT Macrophages mediate innate immune responses that recognise foreign pathogens, and bacterial lipopolysaccharide (LPS) recruits a signalling pathway through Toll-like receptor 4 (TLR4) to induce pro-inflammatory cytokines and...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (9): 1466–1476.
Published: 01 May 2008
... lipopolysaccharide (LPS) suppresses Notch signaling via the direct modification of Notch by the nitration of tyrosine residues in macrophages. In the RAW264.7 macrophage cell line and in rat primary alveolar macrophages, LPS was found to inhibit Notch1 intracellular domain (Notch1-IC) transcription activity, which...
Includes: Supplementary data
Journal Articles
J Cell Sci (2004) 117 (20): 4749–4756.
Published: 15 September 2004
... necrosis factor α and interleukin 1β, and by lipopolysaccharide (LPS), but is hardly expressed in other cells of the vascular wall such as primary smooth muscle cells and fibroblasts. Regulation of HERC5 gene expression suggests a critical role for the transcription factor NF-κB. In contrast to mRNA...
Journal Articles
J Cell Sci (2002) 115 (12): 2603–2611.
Published: 15 June 2002
... lipopolysaccharide (LPS)-cellular activation, such as CD14, heat shock protein(hsp) 70, 90, Chemokine receptor 4 (CXCR4), growth differentiation factor 5(GDF5) and Toll-like receptor 4 (TLR4), are present in microdomains following LPS stimulation. Lipid raft integrity is essential for LPS-cellular activation, since...