...Hanna Thoma; Luisa Grünewald; Silke Braune; Elisabeth Pasch; Manfred Alsheimer ABSTRACT SUN domain proteins are conserved proteins of the nuclear envelope and key components of the LINC complexes (for ‘linkers of the nucleoskeleton and the cytoskeleton’). Previous studies have demonstrated...

... and cytoskeleton complexes (LINC complexes) and are formed by the interaction of SUN and KASH domain proteins in the nuclear envelope. Ample evidence suggests that SUN–KASH complexes form higher-order assemblies to withstand and transfer forces across the nuclear envelope. Herein, we present a review of recent...

... © 2019. Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Highlighted Article: Two emerin proteins in Drosophila regulate the abundance of Klarsicht at the nucleus, which is necessary for the proper movement of myonuclei. LINC complex...

.... , Shanahan , C. , Burke , B. , Stahl , P. D. and Hodzic , D. ( 2006 ). Coupling of the nucleus and cytoplasm: role of the LINC complex . J. Cell Biol.   172 , 41 - 53 . 10.1083/jcb.200509124 Dahl , K. N. , Kahn , S. M. , Wilson , K. L. and Discher , D. E. ( 2004...

...Axel Poulet; Céline Duc; Maxime Voisin; Sophie Desset; Sylvie Tutois; Emmanuel Vanrobays; Matthias Benoit; David E. Evans; Aline V. Probst; Christophe Tatout ABSTRACT The linker of nucleoskeleton and cytoskeleton (LINC) complex is an evolutionarily well-conserved protein bridge connecting...

... evolutionary comparison of eukaryotic nucleocytoplasmic bridging complexes suggests that they might have evolved from protein complexes involved in attaching centrosomes to the nuclear envelope. KASH protein SUN protein Opisthokonta Archeaplastida Evolution Coiled-coil domain LINC complex...

...; however, only two integral protein complexes span the nuclear envelope and connect the inside of the nucleus to the cytoplasm. The nuclear pore complex (NPC) acts as a gateway for molecular exchange between the interior of the nucleus and the cytoplasm, whereas so-called LINC complexes physically link...

... of microtubule motors, as well as Sad1p, UNC-84 (SUN) domain and Klarsicht, ANC-1, Syne homology (KASH) domain proteins (LINC complex) that function to connect nuclei to the cytoskeleton. We focus on how these proteins and various mechanisms move nuclei during vertebrate development, including processes related...

... that the EDMD mutation L535P disrupts the nuclear mechanical response specifically in muscle nuclei. Inhibiting lamin prenylation rescued the mechanical response of the EDMD nuclei, reversed the muscle phenotypes and led to normal motility. The LINC complex and emerin were also required to regulate...

... in migrating fibroblasts closely coincided with the center point of the traction-force balance, called the point of maximum tension (PMT). Positioning of the nucleus close to the PMT required nucleus–cytoskeleton connections through linker of nucleoskeleton-to-cytoskeleton (LINC) complexes. Although...

... 2014 LINC complex Nuclear envelope Spindle pole body In eukaryotic cells, the activity of the cyclin-dependent kinase Cdk1 (also known as Cdc2, Cdc28 or mitosis-promoting factor) determines the timing of mitotic entry and cell division ( Nurse, 1990 ). Cdk1 activity and the transition...

... edge and this movement is required for proper cell migration. Nuclear movement requires the LINC complex components nesprin-2G and SUN2, which form transmembrane actin-associated nuclear (TAN) lines at the nuclear envelope. Here we show that the nuclear envelope protein Samp1 (NET5) is involved...

...Cecilia Östlund; Eric S. Folker; Jason C. Choi; Edgar R. Gomes; Gregg G. Gundersen; Howard J. Worman The linker of nucleoskeleton and cytoskeleton (LINC) complex is situated in the nuclear envelope and forms a connection between the lamina and cytoskeletal elements. Sun1, Sun2 and nesprin-2...