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Rosa-Ana González-Polo, Patricia Boya, Anne-Laure Pauleau, Abdelali Jalil, Nathanael Larochette, Sylvie Souquère, Eeva-Liisa Eskelinen, Gérard Pierron, Paul Saftig, Guido Kroemer
Journal: Journal of Cell Science
J Cell Sci (2005) 118 (14): 3091–3102.
Published: 15 July 2005
... inactivation of LAMP2 by RNA interference or by homologous recombination leads to autophagic vacuolization in nutrient-depleted cells. Cells that lack LAMP2 expression showed an enhanced accumulation of vacuoles carrying the marker LC3, yet a decreased colocalization of LC3 and lysosomes, suggesting that the...