... as FAP147. A previous cryo-electron microscopy analysis has revealed the localization of FAP147 to the central apparatus of the axoneme. Here, we generated Mycbpap -knockout mice and demonstrated the essential role of Mycbpap in male fertility. Deletion of Mycbpap led to disrupted centrosome–nuclear...

..., with possibly broader implications for IFs in general. Krt1 −/− ; Krt10 −/− mice were derived from single K1 and K10 knockout mice (T. Magin and J.R., unpublished) ( Reichelt et al., 2001 ) by breeding over two generations. Double heterozygous Krt1 −/− ; Krt1 +/ − mice resulting from...

... ) ‡ These authors contributed equally to this work 1 5 2009 © The Company of Biologists Limited 2009 2009 Desmosome Epidermis Hypotrichosis simplex of the scalp Knockout mice Psoriasis Lessons from human diseases and engineered mouse models have established the importance...

...-acetylcholine-receptor subunits and knockout mice demonstrated pivotal role for the α3β2 channel in mediating acetylcholine-dependent chemokinesis. Signaling pathways downstream of α3β2 included activation of the protein-kinase-C isoform δ and RhoA-dependent events. The nicotinergic chemotaxis of keratinocytes...

... Raf effectors comes from mouse genetics. A- Raf -knockout mice are born alive, can survive up to 21 days post-partum and display neurological and intestinal abnormalities ( Pritchard et al.,1996 ). The B- Raf knockout is embryonic lethal and, in mice, embryos show overall growth retardation...