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Keywords: Knockout
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Journal Articles
J Cell Sci (2020) 133 (20): jcs243972.
Published: 21 October 2020
... roles of PTPRT in hippocampal neurogenesis and synaptic function are involved in the pathogenesis of depressive disorder. PTPRT Depression Knockout Tyrosine dephosphorylation Synaptic function Hippocampal neurogenesis Depressive disorder is a major health problem with a high...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (23): 4379–4387.
Published: 1 December 2016
... -knockout male mice showed severe subfertility with a defect in sperm motility as well as a significant disorganization in the fibrous sheath. Further, abnormal configuration of doublet microtubules was observed in the Cabyr -knockout spermatozoa, suggesting that the fibrous sheath is important...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (15): 2640–2650.
Published: 1 August 2009
... in SR architecture in obscurin knockout mice are also associated with alterations in several SR or SR-associated proteins, such as ankyrin-2 and β-spectrin. Finally, obscurin knockout mice display centralized nuclei in skeletal muscles as a sign of mild myopathy, but have normal sarcomeric structure...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (5): 735–744.
Published: 1 March 2009
... Knockout Mouse Hippocampus GluR1 GluR4 Synaptic plasticity The excitatory neurotransmitter glutamate activates α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors, N-methyl-D-aspartate (NMDA) receptors and kainate receptors. Fast excitatory transmission in the brain is mainly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (15): 3387–3395.
Published: 1 August 2005
..., as well as heterologous organotypic co-cultures of mouse fibroblasts and human keratinocytes, showed that the altered keratinocyte proliferation is caused primarily by CTSL-deficiency in keratinocytes. In the absence of EGF, wild type and CTSL-knockout keratinocytes proliferate with the same rates, while...
Journal Articles
J Cell Sci (2005) 118 (5): 929–936.
Published: 1 March 2005
... plays a specific role in growth plate morphogenesis and function. * Author for correspondence (e-mail: faessler@biochem.mpg.de ) 8 12 2004 © The Company of Biologists Limited 2005 2005 Integrin Knockout Cartilage Growth plate Proliferation The major part...
Journal Articles
J Cell Sci (2005) 118 (5): 1045–1060.
Published: 1 March 2005
... proliferation, survival and migration through a mechanism independent of its adhesive function. We have generated a conditional knockout mouse strain, in which the gene encoding the β4 integrin subunit ( Itgb4 ) was inactivated only in small stretches of the skin. These mice were viable and permitted...