... of polycystin-2 and instead resembled the properties of polycystin-2L1, in particular regarding its permeability for Ca 2+ ions. Homology modeling of the ion translocation pathway of polycystin-2 poreL1 argues for a wider pore in polycystin-2 poreL1 than in polycystin-2. In Pkd2 poreL1 knock-in mice in which...

.... In this study, we developed knock-in mice expressing Sqstm1 fused to GFP ( Sqstm1-GFP KI/+ ). Using these Sqstm1-GFP KI/+ mice, we revealed for the first time the dynamics of endogenous Sqstm1 in living cells. Sqstm1–GFP was translocated to a restricted area of LC3-positive structures, which primarily...

... ) is co-expressed with Cx45 in certain types of retinal interneurons. To determine whether these two connexins have similar functions and whether Cx36 can compensate for Cx45, we generated knock-in mice in which DNA encoding Cx45 was replaced with that encoding Cx36. Neuron-directed replacement of Cx45...

... of its kinase activity. In light of these results, and to show that the hDlg-PSF complex is regulated by p38γ independently of its kinase activity, we used cells derived from knock-in mice expressing catalytically inactive p38γ. Since the p38MAPKs are a clear example of functional redundancy owing...

... Knock-in mice Coupling compartment Subpulmonary outlet Low voltage QRS complex © The Company of Biologists Limited 2006 2006 18 11 2005 * Corresponding author (e-mail: genetik@uni-bonn.de ) ...