1-20 of 65
Keywords: Kinetochore
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (14): jcs254037.
Published: 23 July 2021
... to the centromeres depends on BUBR1, MEI-S332 and kinetochore protein SPC105R. Although BUBR1 stabilizes microtubule attachments in Drosophila oocytes, it is not required for cohesion maintenance during meiosis I. We propose at least three populations of PP2A-B56 regulate meiosis, two of which depend on SPC105R...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (1): jcs251025.
Published: 08 January 2021
... amphitelic attachments to microtubules emanating from opposing spindle poles. The astrin–kinastrin (astrin is also known as SPAG5 and kinastrin as SKAP) complex, also containing DYNLL1 and MYCBP, is a spindle and kinetochore protein complex with important roles in bipolar spindle formation, chromosome...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (18): jcs247940.
Published: 17 September 2020
... show that this protocol could be successfully employed for the characterization of the protein–protein interaction network of the kinetochore protein Ndc80 by immunoprecipitation coupled with mass spectrometry. This synchronization method significantly expands the versatility and applicability of RPE-1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (16): jcs246025.
Published: 25 August 2020
... to polar unattached kinetochores to facilitate chromosome alignment. The spindle checkpoint protein BubR1 (also known as BUB1B) has been reported as a CENP-E interacting partner, but the extent to which BubR1 contributes to CENP-E localization at kinetochores has remained controversial. Here we define...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs242610.
Published: 24 July 2020
... A,B). JMJD2D can specifically demethylate lysine 9 of histone H3 (H3K9) ( Krishnan and Trievel, 2013 ; Shin and Janknecht, 2007 ). We have previously shown that JMJD2D tethering to all human pericentromeres causes chromosome mis-segregation and affects kinetochore proteins ( Molina et al., 2016b...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs245753.
Published: 30 June 2020
... replication and chromosome segregation. The parasite undergoes atypical endomitosis and endoreduplication with an intact nuclear membrane and intranuclear mitotic spindle. To understand these diverse modes of Plasmodium cell division, we have studied the behaviour and composition of the outer kinetochore...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (12): jcs224147.
Published: 21 June 2019
...Hiral Shah; Kanika Rawat; Harsh Ashar; Rajesh Patkar; Johannes Manjrekar ABSTRACT The outer kinetochore DASH complex (also known as the Dam1 complex) ensures proper spindle structure and chromosome segregation. While DASH complex protein requirement diverges among different yeasts, its role...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (12): jcs231589.
Published: 17 June 2019
...Banafsheh Etemad; Abel Vertesy; Timo E. F. Kuijt; Carlos Sacristan; Alexander van Oudenaarden; Geert J. P. L. Kops ABSTRACT The spindle assembly checkpoint (SAC) ensures proper chromosome segregation by monitoring kinetochore–microtubule interactions. SAC proteins are shed from kinetochores once...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (16): jcs214577.
Published: 16 August 2018
...Julie K. Monda; Iain M. Cheeseman ABSTRACT Accurate chromosome segregation critically depends on the formation of attachments between microtubule polymers and each sister chromatid. The kinetochore is the macromolecular complex that assembles at the centromere of each chromosome during mitosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (1): jcs212159.
Published: 08 January 2018
...Patrícia A. Simões; Ricardo Celestino; Ana X. Carvalho; Reto Gassmann ABSTRACT In mitosis, the molecular motor dynein is recruited to kinetochores by the Rod–Zw10–Zwilch complex (RZZ) and Spindly to control spindle assembly checkpoint (SAC) signaling and microtubule attachment. How the ubiquitous...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2266–2276.
Published: 15 July 2017
...Zuojun Yue; Shinya Komoto; Marek Gierlinski; Debora Pasquali; Etsushi Kitamura; Tomoyuki U. Tanaka ABSTRACT Proper chromosome segregation in mitosis relies on correct kinetochore interaction with spindle microtubules. In early mitosis, each kinetochore usually interacts with the lateral side...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2017) 130 (8): 1404–1412.
Published: 15 April 2017
...Hayley Pemble; Praveen Kumar; Jeffrey van Haren; Torsten Wittmann ABSTRACT Error-free chromosome segregation requires dynamic control of microtubule attachment to kinetochores, but how kinetochore–microtubule interactions are spatially and temporally controlled during mitosis remains incompletely...
Journal Articles
J Cell Sci (2015) 128 (24): 4572–4587.
Published: 15 December 2015
... centromeric factors and chromatin modifiers. This analysis revealed four classes of factors that influence CENP-A assembly. Interestingly, many kinetochore structural components induced de novo CENP-A assembly at the ectopic site. We showed that these components work by recruiting CENP-C and subsequently...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (18): 3363–3374.
Published: 15 September 2015
... protein machines called kinetochores. This Commentary aims to document recent advances concerning the two kinetochore-based force-generating mechanisms that drive mitotic chromosome congression in vertebrate cells: depolymerisation-coupled pulling (DCP) and lateral sliding. We aim to explore how...
Journal Articles
J Cell Sci (2015) 128 (6): 1204–1216.
Published: 15 March 2015
...Lénaïg Défachelles; Sarah G. Hainline; Alexandra Menant; Laura A. Lee; Roger E. Karess ABSTRACT Proper kinetochore recruitment and regulation of dynein and the Mad1–Mad2 complex requires the Rod–Zw10–Zwilch (RZZ) complex. Here, we describe rod Z3 , a maternal-effect Drosophila mutation changing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (1): 171–184.
Published: 01 January 2015
...James Bancroft; Philip Auckland; Catarina P. Samora; Andrew D. McAinsh ABSTRACT A key step of mitosis is the congression of chromosomes to the spindle equator. Congression is driven by at least two distinct mechanisms: (1) kinetochores slide along the microtubule lattice using the plus-end directed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (19): 4225–4233.
Published: 01 October 2014
... of lagging chromosomes during anaphase. Lagging chromosomes are a hallmark of chromosomal instability (CIN) arising from persistent errors in kinetochore–microtubule (kMT) attachment. To determine whether the loss of STAG2 increases the rate of formation of kMT attachment errors or decreases the rate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (16): 3415–3423.
Published: 15 August 2014
...Priyanka Ghongane; Maria Kapanidou; Adeel Asghar; Sabine Elowe; Victor M. Bolanos-Garcia ABSTRACT Knl1 (also known as CASC5, UniProt Q8NG31) is an evolutionarily conserved scaffolding protein that is required for proper kinetochore assembly, spindle assembly checkpoint (SAC) function and chromosome...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2818–2824.
Published: 01 July 2014
...Mohammed Abdullahel Amin; Go Itoh; Kenji Iemura; Masanori Ikeda; Kozo Tanaka ABSTRACT The cytoplasmic linker protein (CLIP)-170, an outer kinetochore protein, has a role in kinetochore–microtubule attachment and chromosome alignment during mitosis. However, the mechanism by which CLIP-170...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (4): 871–884.
Published: 15 February 2014
... with kinetochores during mitosis, which is required for proper chromosome segregation. The outer kinetochore protein KNL1 (also known as CASC5, Blinkin and AF15Q14) is the receptor for Bub proteins, but the exact nature of the functional binding sites on KNL1 are yet to be determined. Here, we show that KNL1...
Includes: Supplementary data