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Keywords: Kinesin-5
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Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (10): jcs257543.
Published: 03 June 2021
... the oocyte cytoplasm, that is divide it into polygonal structures, dominated by hexagons, in a kinesin-5-dependent manner, while inter-aster MTs form ‘mini-spindles’. A computational model of multiple asters interacting with kinesin-5 can reproduce both tessellation patterns and mini-spindles in a manner...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs246801.
Published: 23 June 2020
... embryogenesis. It is unknown how these proteins are linked to mitosis. Here, we show that Crb, Galla-2 and Xpd regulate nuclear division in the syncytial embryo by interacting with Klp61F, the Drosophila mitotic Kinesin-5 associated with bipolar spindles. Crb, Galla-2 and Xpd physically interact with Klp61F...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2017) 130 (4): 725–734.
Published: 15 February 2017
...Ofer Shapira; Alina Goldstein; Jawdat Al-Bassam; Larisa Gheber ABSTRACT The bipolar kinesin-5 Cin8 switches from minus- to plus-end-directed motility under various conditions in vitro . The mechanism and physiological significance of this switch remain unknown. Here, we show that under high ionic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4147–4159.
Published: 15 September 2013
...Vladimir Fridman; Adina Gerson-Gurwitz; Ofer Shapira; Natalia Movshovich; Stefan Lakämper; Christoph F. Schmidt; Larisa Gheber Summary In this study, we examined the anaphase functions of the S. cerevisiae kinesin-5 homolog Kip1. We show that Kip1 is attached to the mitotic spindle midzone during...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (6): 873–878.
Published: 15 March 2011
...Rachel Avunie-Masala; Natalia Movshovich; Yael Nissenkorn; Adina Gerson-Gurwitz; Vladimir Fridman; Mardo Kõivomägi; Mart Loog; M. Andrew Hoyt; Arieh Zaritsky; Larisa Gheber The kinesin-5 Saccharomyces cerevisiae homologue Cin8 is shown here to be differentially phosphorylated during late anaphase...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (22): 4168–4176.
Published: 15 November 2009
..., and they require ongoing microtubule dynamics and kinesin-5 (also known as Eg5) activity. Inhibition of topoisomerase II in mitosis, which prevents decatenation and separation of chromatids, circumvents the loss of cohesion and restores integrity of the spindle poles. Although these results do not rule out roles...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (9): 1295–1300.
Published: 01 May 2009
...Julie Cahu; Thomas Surrey The organization of the microtubule cytoskeleton depends crucially on crosslinking motors that arrange microtubules in space. Kinesin-5 is such an essential motile crosslinker. It is unknown whether its organizing capacity during bipolar spindle formation depends on its...
Journal Articles
J Cell Sci (2008) 121 (23): 3912–3921.
Published: 01 December 2008
... with Nek6 or Nercc1 in mammalian cells causes prometaphase-metaphase arrest, and depletion of Nercc1 from Xenopus egg extracts prevents normal spindle assembly. Herein we show that Nek6 is constitutively associated with Eg5 (also known as Kinesin-5 and Kif11), a kinesin that is necessary for spindle...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (15): 2529–2539.
Published: 01 August 2008
...Natalia Movshovich; Vladimir Fridman; Adina Gerson-Gurwitz; Inbal Shumacher; Irena Gertsberg; Alexander Fich; M. Andrew Hoyt; Benjamin Katz; Larisa Gheber We examined spindle elongation in anaphase in Saccharomyces cerevisiae cells mutated for the kinesin-5 motor proteins Cin8 and Kip1. Cells were...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (14): 2293–2300.
Published: 15 July 2008
...Aaron C. Groen; Daniel Needleman; Clifford Brangwynne; Christain Gradinaru; Brandon Fowler; Ralph Mazitschek; Timothy J. Mitchison The tetrameric plus-end-directed motor, kinesin-5, is essential for bipolar spindle assembly. Small-molecule inhibitors of kinesin-5 have been important tools...
Includes: Multimedia, Supplementary data