... of IFT-A and IFT-B subcomplexes and the motors kinesin-2 and IFT dynein. At the tip, anterograde trains are remodeled for retrograde IFT, a process that in Chlamydomonas involves kinesin-2 release and train fragmentation. However, the degree of train disassembly at the tip remains unknown. Here, we...

...-1/ Summary: The armadillo protein p0071 controls directional vesicular transport mediated by the KIF3 (kinesin-2) complex, and secretion of respective cancer-relevant cargos from neuroendocrine and pancreatic tumor cells. p0071 Chromogranin MMP9 Kinesin-2 KIF3 Protein transport...

...Brandon S. Carpenter; Renee L. Barry; Kristen J. Verhey; Benjamin L. Allen ABSTRACT GLI transport to the primary cilium and nucleus is required for proper Hedgehog (HH) signaling; however, the mechanisms that mediate these trafficking events are poorly understood. Kinesin-2 motor proteins regulate...

... is known to associate with microtubules in three ways: through interaction with the plus-end tracking protein EB1, direct binding through a C-terminal basic region, and through interaction with the plus-end motor kinesin-2. Here we report that the middle region of APC has a previously unidentified...