...Eryn E. Dixon; Demetrios S. Maxim; Victoria L. Halperin Kuhns; Allison C. Lane-Harris; Patricia Outeda; Andrew J. Ewald; Terry J. Watnick; Paul A. Welling; Owen M. Woodward ABSTRACT Cystogenesis is a morphological consequence of numerous genetic diseases of the epithelium. In the kidney...

... and yolk sac edema, body axis curvature and hydrocephaly. Notably, in sept7b morphants we detected strong left–right asymmetry defects in the heart and lateral plate mesoderm ( situs inversus ), reduced fluid flow in the kidney, the formation of kidney cysts and loss of glomerular filtration barrier...

...}}{10^{z({\Delta}E{/}s)}-1},\ \] \end{document} where a is the respective activity and z , the respective charge number. * Author for correspondence (e-mail: [email protected] ) 24 1 2009 © The Company of Biologists Limited 2009 2009 Kidney Renal cell...

... assembly. ‡ Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this work 11 12 2007 © The Company of Biologists Limited 2008 2008 Epithelial cells G proteins G12 Kidney Tight junctions The epithelial cell...

... sinusoids and kidney outer medulla vasa recta at P7, which most likely caused the ischemic necrosis observed by P14 in hepatocytes and renal tubular epithelia. Those that survived to adulthood showed similar, but milder, vascular anomalies in both liver and kidney, and females were infertile with varying...

...Uwe Anzenberger; Nana Bit-Avragim; Stefan Rohr; Franziska Rudolph; Bastian Dehmel; Thomas E. Willnow; Salim Abdelilah-Seyfried Megalin/LRP2 is an endocytic receptor in the proximal tubules of the mammalian kidney that plays a central role in the clearance of metabolites from the glomerular filtrate...

... adult tissues are still largely unknown. We have detected substantial levels of the EphB2 and EphB6 receptors and the ephrin-B1 ligand in the adult mouse kidney by RT-PCR amplification. Immunolocalization experiments revealed that EphB2 is localized in the tubules of the inner and outer medulla...

... organic anion accumulation are involved in the process of cystogenesis, including the Na,K-ATPase. * Author for correspondence (e-mail: [email protected] ) 27 11 2003 © The Company of Biologists Limited 2004 2004 Primary culture Kidney Tubulogenesis Matrigel Transport...

... of F-actin ( Klussmann et al.,2001b ; Valenti et al.,2000 ; Tamma et al.,2001 ). PGE 2 Aquaporin AQP2 Rho Vasopressin Kidney © The Company of Biologists Limited 2003 2003 23 4 2003 * Author for correspondence (e-mail: [email protected] ) AVP regulates...

...Nellie Y. Loh; Sarah E. Newey; Kay E. Davies; Derek J. Blake ABSTRACT Dystrophin is the key component in the assembly and maintenance of the dystrophin-associated protein complex (DPC) in skeletal muscle. In kidney, dystroglycan, an integral component of the DPC, is involved in kidney epithelial...

..., pepsinogen, by regulated exocytosis, do not appear to express lasp-1. Similarly, lasp-1 was not detected in pancreatic acinar cells, which secrete enzymes by similar mechanisms and also contain relatively low levels of F-actin. Lasp-1 also was not detectable in proximal tubules in the kidney...

... high levels of expression in brain, drebrin was present in stomach and to a lesser degree in kidney, colon, and urinary bladder. Drebrin protein detected in the non-brain organs migrated faster through SDS-PAGE gels, indicating that the lower molecular weight embryonic brain isoform (E2) may...

... set of antibody reagents. Immunoblot analysis demonstrated that adseverin was highly expressed in mouse kidney and intestine at all stages of development and in human fetal and adult kidney. In contrast and as reported previously, gelsolin was expressed much more widely in both murine and human...

...Jean-Marc Verbavatz; Tonghui Ma; Renée Gobin; A. S. Verkman ABSTRACT Freeze-fracture electron microscopy (FFEM) of kidney collecting duct, muscle, astrocytes in brain, and other mammalian tissues has revealed regular square arrays of intramembrane particles called orthogonal arrays of particles...

...Mats Falk; Katriina Salmivirta; Madeleine Durbeej; Erik Larsson; Marja Ekblom; Dietmar Vestweber; Peter Ekblom ABSTRACT Laminin-1 has previously been shown to be of major importance for the development of kidney tubules. Antibodies against fragments E8 and E3 of laminin-1 perturb kidney development...

... studies are now required to investigate the potential importance of the factor in vivo. * Author for correspondence (e-mail: [email protected] ) 21 07 1995 27 09 1995 © 1995 by Company of Biologists 1995 glomerulus HGF/SF mesangial cell met kidney...

... to epithelia and is up-regulated in parallel with morphogenetic events, tumorigenesis, and epithelial repair. During development of the kidney, lung, and skin, we found that β6 is expressed by specific types of epithelial cells, whereas it is mostly undetectable in normal adult kidney, lung and skin...

...Dennis Brown; Ivan Sabolic ABSTRACT The plasma membrane composition of virtually all eukaryotic cells is maintained and continually modified by the recycling of specific protein and lipid components. In the kidney collecting duct, urinary acidification and urinary concentration are physiologically...

...D. Herzlinger; R. Abramson; D. Cohen ABSTRACT The transporting epithelia of the kidney are derived from an embryonic rudiment containing two distinct cell populations: ureteric bud epithelia and mesenchymal cells of the metanephric blastema. The ureteric bud is a caudal outgrowth of the Wolffian...

... of the kidney glomerulus. On collagen, fibronectin, laminin and vitronectin, the number and intensity of talin-focal contacts increased with time. Talin-containing focal contacts were present in mesangial cells within 2 h of plating and in control cells (HT1080 and Rugli) within 1 h. Integrin α-chains...