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Keywords: Keratin
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Journal Articles
J Cell Sci (2022) 135 (20): jcs260594.
Published: 26 October 2022
...Erez Cohen; Craig Johnson; Catherine J. Redmond; Raji R. Nair; Pierre A. Coulombe ABSTRACT A large group of keratin genes ( n =54 in the human genome) code for intermediate filament (IF)-forming proteins and show differential regulation in epithelial cells and tissues. Keratin expression can...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (18): jcs259004.
Published: 15 September 2021
...Lisa te Molder; Jose M. de Pereda; Arnoud Sonnenberg ABSTRACT Hemidesmosomes (HDs) are specialized multiprotein complexes that connect the keratin cytoskeleton of epithelial cells to the extracellular matrix (ECM). In the skin, these complexes provide stable adhesion of basal keratinocytes...
Journal Articles
J Cell Sci (2021) 134 (15): jcs250167.
Published: 3 August 2021
...Sujin Kim; Younglan Lim; So-Young Lee; Han-Na Yoon; Hayan Yi; Kwi-Hoon Jang; Nam-On Ku ABSTRACT Keratin 8 (K8) is the cytoskeletal intermediate filament protein of simple-type epithelia. Mutations in K8 predispose the affected individual and transgenic mouse to liver disease. However, the role...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs254094.
Published: 30 October 2020
...Justin T. Jacob; Raji R. Nair; Brian G. Poll; Christopher M. Pineda; Ryan P. Hobbs; Michael J. Matunis; Pierre A. Coulombe ABSTRACT Keratin 17 ( KRT17 ; K17), a non-lamin intermediate filament protein, was recently found to occur in the nucleus. We report here on K17-dependent differences...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs254094.
Published: 30 October 2020
...Justin T. Jacob; Raji R. Nair; Brian G. Poll; Christopher M. Pineda; Ryan P. Hobbs; Michael J. Matunis; Pierre A. Coulombe ABSTRACT Keratin 17 ( KRT17 ; K17), a non-lamin intermediate filament protein, was recently found to occur in the nucleus. We report here on K17-dependent differences...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (18): jcs229534.
Published: 26 September 2019
...So-Young Lee; Sujin Kim; Younglan Lim; Han-Na Yoon; Nam-On Ku ABSTRACT Intermediate filament protein keratin 8 (K8) binds to heat shock protein 70 (Hsp70) and p38 MAPK, and is phosphorylated at Ser74 by p38α (MAPK14, hereafter p38). However, a p38 binding site on K8 and the molecular mechanism...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (18): jcs229534.
Published: 26 September 2019
...So-Young Lee; Sujin Kim; Younglan Lim; Han-Na Yoon; Nam-On Ku ABSTRACT Intermediate filament protein keratin 8 (K8) binds to heat shock protein 70 (Hsp70) and p38 MAPK, and is phosphorylated at Ser74 by p38α (MAPK14, hereafter p38). However, a p38 binding site on K8 and the molecular mechanism...
Includes: Supplementary data
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J Cell Sci (2015) 128 (24): 4475–4486.
Published: 15 December 2015
... of the cytoskeleton to nuclear mechanotransduction remains unclear. In this study, we examine how crosstalk between the cytolinker plectin and F-actin controls keratin network organisation and the 3D nuclear morphology of keratinocytes. Using micro-patterned surfaces to precisely manipulate cell shape, we find...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4475–4486.
Published: 15 December 2015
... of the cytoskeleton to nuclear mechanotransduction remains unclear. In this study, we examine how crosstalk between the cytolinker plectin and F-actin controls keratin network organisation and the 3D nuclear morphology of keratinocytes. Using micro-patterned surfaces to precisely manipulate cell shape, we find...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5635–5644.
Published: 15 December 2013
...Catharina M. Alam; Jonas S. G. Silvander; Ebot N. Daniel; Guo-Zhong Tao; Sofie M. Kvarnström; Parvez Alam; M. Bishr Omary; Arno Hänninen; Diana M. Toivola Summary Keratin intermediate filament (IF) proteins are epithelial cell cytoskeletal components that provide structural stability and protection...
Includes: Supplementary data
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J Cell Sci (2005) 118 (5): 1081–1090.
Published: 1 March 2005
...Miwako Nishizawa; Ichiro Izawa; Akihito Inoko; Yuko Hayashi; Koh-ichi Nagata; Tomoya Yokoyama; Jiro Usukura; Masaki Inagaki Keratins 8 and 18 (K8/18) are major components of the intermediate filaments (IFs) of simple epithelia. We report here the identification of a novel protein termed trichoplein...
Journal Articles
J Cell Sci (2004) 117 (11): 2295–2307.
Published: 1 May 2004
... envelope proteins involucrin, loricrin, filaggrin, and of the keratins K1 and K5 were significantly altered in cathepsin D-deficient mice. Stratum corneum morphology in cathepsin D-deficient mice was impaired, with increased numbers of corneocyte layers and faint staining of the cornified envelope only...
Journal Articles
J Cell Sci (2004) 117 (2): 133–141.
Published: 15 January 2004
..., T. M. and Weber, K. ( 2001 ). Genes for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. J. Cell Sci. 114 , 2569 -2575. Hirokawa, N., Terada, S., Funakoshi, T...
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