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Keywords: Keratin
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Journal Articles
J Cell Sci (2021) 134 (18): jcs259004.
Published: 15 September 2021
...Lisa te Molder; Jose M. de Pereda; Arnoud Sonnenberg ABSTRACT Hemidesmosomes (HDs) are specialized multiprotein complexes that connect the keratin cytoskeleton of epithelial cells to the extracellular matrix (ECM). In the skin, these complexes provide stable adhesion of basal keratinocytes...
Journal Articles
J Cell Sci (2021) 134 (15): jcs250167.
Published: 03 August 2021
...Sujin Kim; Younglan Lim; So-Young Lee; Han-Na Yoon; Hayan Yi; Kwi-Hoon Jang; Nam-On Ku ABSTRACT Keratin 8 (K8) is the cytoskeletal intermediate filament protein of simple-type epithelia. Mutations in K8 predispose the affected individual and transgenic mouse to liver disease. However, the role...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs254094.
Published: 30 October 2020
...Justin T. Jacob; Raji R. Nair; Brian G. Poll; Christopher M. Pineda; Ryan P. Hobbs; Michael J. Matunis; Pierre A. Coulombe ABSTRACT Keratin 17 ( KRT17 ; K17), a non-lamin intermediate filament protein, was recently found to occur in the nucleus. We report here on K17-dependent differences...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (18): jcs229534.
Published: 26 September 2019
...So-Young Lee; Sujin Kim; Younglan Lim; Han-Na Yoon; Nam-On Ku ABSTRACT Intermediate filament protein keratin 8 (K8) binds to heat shock protein 70 (Hsp70) and p38 MAPK, and is phosphorylated at Ser74 by p38α (MAPK14, hereafter p38). However, a p38 binding site on K8 and the molecular mechanism...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (15): 2541–2550.
Published: 01 August 2017
...Han-Na Yoon; Sung-Yeon Yoon; Jin-Hyuck Hong; Nam-On Ku ABSTRACT Cytoskeletal keratin 18 (K18) undergoes caspase-mediated digestion during apoptosis, which leads to dramatic disassembly of keratin filaments. We studied the significance of K18 caspase digestion in a mouse model and generated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (17): 3262–3273.
Published: 01 September 2016
...Stéphane Gilbert; Anne Loranger; M. Bishr Omary; Normand Marceau ABSTRACT Keratins are epithelial cell intermediate filament (IF) proteins that are expressed as pairs in a cell-differentiation-regulated manner. Hepatocytes express the keratin 8 and 18 pair (denoted K8/K18) of IFs, and a loss of K8...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (24): 4475–4486.
Published: 15 December 2015
... of the cytoskeleton to nuclear mechanotransduction remains unclear. In this study, we examine how crosstalk between the cytolinker plectin and F-actin controls keratin network organisation and the 3D nuclear morphology of keratinocytes. Using micro-patterned surfaces to precisely manipulate cell shape, we find...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5635–5644.
Published: 15 December 2013
...Catharina M. Alam; Jonas S. G. Silvander; Ebot N. Daniel; Guo-Zhong Tao; Sofie M. Kvarnström; Parvez Alam; M. Bishr Omary; Arno Hänninen; Diana M. Toivola Summary Keratin intermediate filament (IF) proteins are epithelial cell cytoskeletal components that provide structural stability and protection...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2810–2822.
Published: 15 August 2010
...Pauline B. McIntosh; Peter Laskey; Kate Sullivan; Clare Davy; Qian Wang; Deborah J. Jackson; Heather M. Griffin; John Doorbar The keratin IF network of epidermal keratinocytes provides a protective barrier against mechanical insult, it is also a major player in absorbing stress in these cells...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (6): 825–833.
Published: 15 March 2008
... family members. Previous studies, including the phenotypic analyses of knockout mice, failed to reveal the biological function of epiplakin. Using in vitro binding assays, we show here that all but one of the 16 PRDs of mouse epiplakin bind to keratins of basal keratinocytes. Nevertheless, in primary...
Journal Articles
J Cell Sci (2005) 118 (5): 1081–1090.
Published: 01 March 2005
...Miwako Nishizawa; Ichiro Izawa; Akihito Inoko; Yuko Hayashi; Koh-ichi Nagata; Tomoya Yokoyama; Jiro Usukura; Masaki Inagaki Keratins 8 and 18 (K8/18) are major components of the intermediate filaments (IFs) of simple epithelia. We report here the identification of a novel protein termed trichoplein...
Journal Articles
J Cell Sci (2004) 117 (11): 2295–2307.
Published: 01 May 2004
... envelope proteins involucrin, loricrin, filaggrin, and of the keratins K1 and K5 were significantly altered in cathepsin D-deficient mice. Stratum corneum morphology in cathepsin D-deficient mice was impaired, with increased numbers of corneocyte layers and faint staining of the cornified envelope only...
Journal Articles
J Cell Sci (2004) 117 (2): 133–141.
Published: 15 January 2004
... for intermediate filament proteins and the draft sequence of the human genome: novel keratin genes and a surprisingly high number of pseudogenes related to keratin genes 8 and 18. J. Cell Sci. 114 , 2569 -2575. Hirokawa, N., Terada, S., Funakoshi, T. and Takeda, S. ( 1997 ). Slow axonal transport...
Journal Articles
J Cell Sci (2003) 116 (22): 4629–4638.
Published: 15 November 2003
...Guo-Zhong Tao; Diana M. Toivola; Bihui Zhong; Sara A. Michie; Evelyn Z. Resurreccion; Yoshitaka Tamai; Makoto M. Taketo; M. Bishr Omary Keratin transgenic mouse models and the association of human keratin mutations with liver disease highlight the importance of keratins in protecting the liver from...
Journal Articles
J Cell Sci (2003) 116 (11): 2295–2302.
Published: 01 June 2003
.... There are several unexpected differences. F. rubripes has a sizeable excess of keratin type I genes over keratin type II genes. Four of the six keratin type II genes map close to four keratin type I genes. Thus, a single keratin II gene cluster(as in mammals) seems excluded. Although a continuous genome sequence...
Journal Articles
J Cell Sci (2002) 115 (21): 4133–4148.
Published: 01 November 2002
... phosphorylation Keratin Intermediate filament Plectin 14-3-3 Live cell imaging Green fluorescent protein © The Company of Biologists Limited 2002 2002 7 8 2002 * Author for correspondence (e-mail: leube@mail.uni-mainz.de ) Very little is known about the molecular...
Includes: Multimedia, Supplementary data