... STIM1 KCNQ National Institutes of Health 10.13039/100000002 R37-NS08174 Wayne E. Crill This paper explores regulation of membrane processes by phosphoinositide kinases. Phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5) P 2 ], which constitutes <1% of total...

.... Coiled-coil Leucine zipper Calmodulin PIP 2 KCNQ Epilepsy M-current Allosteric Phosphatidylinositol(4,5)bisphosphate (PIP 2 ) is a minor (<1%) acidic phospholipid found in the inner leaflet of the cell membrane and plays a vital part in cellular signaling by directly interacting...

... by The Company of Biologists Ltd 2015 Summary: A new dispensable site in the Kv7.2 channel affects its regulation by CaM, such that its function can be rescued by CaM when one of the other two CaM-interaction sites is impaired. Calmodulin PIP 2 KCNQ M-current Signal transduction Kv7.2...

.... , Minor   D. L.   Jr ( 2007 ). Structural insight into KCNQ (Kv7) channel assembly and channelopathy.   Neuron   53 , 663 – 675 . 10.1016/j.neuron.2007.02.010 Jentsch   T. J. , Hübner   C. A. , Fuhrmann   J. C. ( 2004 ). Ion channels: function unravelled by dysfunction.   Nat. Cell...

..., 37075 Göttingen, Germany Author for correspondence ( [email protected] ). 19 11 2012 © 2013. Published by The Company of Biologists Ltd 2013 KCNQ Kv7 Potassium channel Surface expression Traffick Calmodulin Calmodulin (CaM) is a ubiquitous Ca 2+ sensor...

...-mail: [email protected] ) 9 1 2007 © The Company of Biologists Limited 2007 2007 KCNQ M current Epilepsy Axon initial segment Ankyrin-G Targeting Voltage-gated KCNQ (Kv7) potassium channels are of critical importance in excitable tissue. In the nervous system, KCNQ2/3 channel...