...-translational modifications, H-Ras and N-Ras traffic to the PM from the Golgi via the classical exocytic pathway, but the exact mechanism of K-Ras trafficking to the PM from the ER is not fully characterized. ATP5G1 (also known as ATP5MC1) is one of the three proteins that comprise subunit c of the F 0 complex...

... transformation and whether it has a causal role remains unclear. We have investigated Ca 2+ signalling in two human colorectal cancer cell lines and their isogenic derivatives in which the allele encoding oncogenic K-Ras (G13D) was deleted by homologous recombination. We show that agonist-induced Ca 2+ release...

...Carles Barceló; Noelia Paco; Alison J. Beckett; Blanca Alvarez-Moya; Eduard Garrido; Mariona Gelabert; Francesc Tebar; Montserrat Jaumot; Ian Prior; Neus Agell Summary Activating mutations in the K-Ras small GTPase are extensively found in human tumors. Although these mutations induce...