... infection neutralizes the pH of the ERGIC due to the proton channel activity of the viral envelope protein, which is prevented by mutations at Val25. COVID-19 Coronavirus Ion channel Viroporin Virus–host interactions Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen...

... Highlighted Article: PIEZO1 mechanically activated ion channels are enriched in the mouse mammary gland during lactation but are not essential for mammary epithelial cell function or post-lactational regression in vivo . Mammary gland PIEZO1 Ion channel Calcium Lactation Involution...

... in cellular Ca 2+ homeostasis by modulating the endoplasmic reticulum Ca 2+ leak. Ca 2+ signaling LRRC8 Pannexin VRAC Ion channel The importance of leucine-rich repeat-containing 8 (LRRC8) proteins was first realized in B cell development. Identified in a patient suffering from...

...-sensitive TRP channel TRPM2 was present in the phagosomal membrane and that it regulates macrophage bactericidal activity by promoting phagosomal acidification. Bactericidal activity Ion channel Phagosome Macrophages, upon ingesting invading micro-organisms, have the primary function...

... Highlighted Article: The STIM1-interacting protein junctate generates Ca 2+ hotspots that boost phagocytosis independently of STIM1 by promoting Ca 2+ release from ER stores rather than by gating phagosomal Ca 2+ channels. Ca 2+ Capacitive calcium entry Ion channel Junctate Signal transduction...

... in Alzheimer's disease. In the mouse brain, its levels are controlled by the CALHM1 ion channel promoting its clearance by insulin-degrading enzyme. CALHM1 Ion channel Amyloid-β peptide Insulin-degrading enzyme Secretion Alzheimer's disease Alzheimer's disease is a neurodegenerative brain...

...Tom Schilling; Francesc Miralles; Claudia Eder ABSTRACT Ion channels play pivotal roles in regulating important functions of macrophages, such as cytokine and chemokine production, migration, proliferation, phagocytosis and others. In this study, we have identified the transient receptor potential...

...Thomas M. Campbell; Martin J. Main; Elizabeth M. Fitzgerald Summary Various ion channels are expressed in human cancers where they are intimately involved in proliferation, angiogenesis, invasion and metastasis. Expression of functional voltage-gated Na + channels (Na v ) is implicated...

...., Barny, M. A., Rona, J. P. and Bouteau, F. ( 2001 ). Harpin, a hypersensitive response elicitor from Erwinia amylovora , regulates ion channel activities in Arabidopsis thaliana suspension cells. FEBS Lett. 497 , 82 -84. Espinosa, A., Guo, M., Tam, V. C., Fu, Z. Q. and Alfano, J. R. ( 2003...