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Keywords: Invadopodia
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Journal Articles
Journal Articles
J Cell Sci (2022) 135 (12): jcs259576.
Published: 28 June 2022
...Sameena Parveen; Amrita Khamari; Jyothikamala Raju; Marc G. Coppolino; Sunando Datta ABSTRACT Invasion in various cancer cells requires coordinated delivery of signaling proteins, adhesion proteins, actin-remodeling proteins and proteases to matrix-degrading structures called invadopodia. Vesicular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (20): jcs244848.
Published: 22 October 2020
... adhesions (FAs), focal complexes, fibrillar adhesions, podosomes and invadopodia, contain many shared scaffolding and signaling ‘adhesome’ components, as well as distinct molecules that perform specific functions, unique to each adhesion form. In this Hypothesis, we address the pivotal roles of mechanical...
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (20): jcs244848.
Published: 22 October 2020
... adhesions (FAs), focal complexes, fibrillar adhesions, podosomes and invadopodia, contain many shared scaffolding and signaling ‘adhesome’ components, as well as distinct molecules that perform specific functions, unique to each adhesion form. In this Hypothesis, we address the pivotal roles of mechanical...
Journal Articles
J Cell Sci (2020) 133 (9): jcs239152.
Published: 14 May 2020
...Olivia R. Grafinger; Genya Gorshtein; Tyler Stirling; Megan I. Brasher; Marc G. Coppolino ABSTRACT Malignant cancer cells can invade extracellular matrix (ECM) through the formation of F-actin-rich subcellular structures termed invadopodia. ECM degradation at invadopodia is mediated by matrix...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs239152.
Published: 14 May 2020
...Olivia R. Grafinger; Genya Gorshtein; Tyler Stirling; Megan I. Brasher; Marc G. Coppolino ABSTRACT Malignant cancer cells can invade extracellular matrix (ECM) through the formation of F-actin-rich subcellular structures termed invadopodia. ECM degradation at invadopodia is mediated by matrix...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs238964.
Published: 28 April 2020
... is easily adaptable for the analysis of invadopodia and associated extracellular matrix degradation, and likely also of other micron-size punctate structures. This article describes the workflow of the Poji macro, presents several examples of its applications, and also points out limitations, as well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs238964.
Published: 28 April 2020
... is easily adaptable for the analysis of invadopodia and associated extracellular matrix degradation, and likely also of other micron-size punctate structures. This article describes the workflow of the Poji macro, presents several examples of its applications, and also points out limitations, as well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs227116.
Published: 18 October 2019
...Battuya Bayarmagnai; Louisiane Perrin; Kamyar Esmaeili Pourfarhangi; Xavier Graña; Erkan Tüzel; Bojana Gligorijevic ABSTRACT The process of tumor cell invasion and metastasis includes assembly of invadopodia, protrusions capable of degrading the extracellular matrix (ECM). The effect of cell cycle...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (20): jcs227116.
Published: 18 October 2019
...Battuya Bayarmagnai; Louisiane Perrin; Kamyar Esmaeili Pourfarhangi; Xavier Graña; Erkan Tüzel; Bojana Gligorijevic ABSTRACT The process of tumor cell invasion and metastasis includes assembly of invadopodia, protrusions capable of degrading the extracellular matrix (ECM). The effect of cell cycle...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs223172.
Published: 5 June 2019
...Bettina Noll; David Benz; Yannick Frey; Florian Meyer; Manuel Lauinger; Stephan A. Eisler; Simone Schmid; Peter L. Hordijk; Monilola A. Olayioye ABSTRACT Cancer cells degrade the extracellular matrix through actin-rich protrusions termed invadopodia. The formation of functional invadopodia requires...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs223172.
Published: 5 June 2019
...Bettina Noll; David Benz; Yannick Frey; Florian Meyer; Manuel Lauinger; Stephan A. Eisler; Simone Schmid; Peter L. Hordijk; Monilola A. Olayioye ABSTRACT Cancer cells degrade the extracellular matrix through actin-rich protrusions termed invadopodia. The formation of functional invadopodia requires...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (1): jcs203661.
Published: 8 January 2018
..., and act as scaffolds, bringing membrane and cellular components in close proximity in structures known as invadopodia or podosomes. Tks proteins, analogous to the related proteins p47 phox , p40 phox and NoxO1, also facilitate local generation of reactive oxygen species (ROS), which aid in signaling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (1): jcs203661.
Published: 8 January 2018
..., and act as scaffolds, bringing membrane and cellular components in close proximity in structures known as invadopodia or podosomes. Tks proteins, analogous to the related proteins p47 phox , p40 phox and NoxO1, also facilitate local generation of reactive oxygen species (ROS), which aid in signaling...
Includes: Supplementary data
Journal Articles
Journal Articles
In collection:
Adhesion
J Cell Sci (2017) 130 (12): 2036–2048.
Published: 15 June 2017
...Mark A. Eckert; Miguel Santiago-Medina; Thinzar M. Lwin; Jihoon Kim; Sara A. Courtneidge; Jing Yang ABSTRACT The Twist1 transcription factor promotes tumor invasion and metastasis by inducing epithelial–mesenchymal transition (EMT) and invadopodia-mediated extracellular matrix (ECM) degradation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (11): 1965–1978.
Published: 1 June 2017
... an in vitro mechano-invasion assay. This enhancement of invasion is dependent on cofilin (CFL1), a known regulator of invadopodia maturation. Invadopodia are actin-rich structures present in invasive cancer cells that are enzymatically active and degrade the surrounding extracellular matrix to facilitate...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2017) 130 (11): 1965–1978.
Published: 1 June 2017
... an in vitro mechano-invasion assay. This enhancement of invasion is dependent on cofilin (CFL1), a known regulator of invadopodia maturation. Invadopodia are actin-rich structures present in invasive cancer cells that are enzymatically active and degrade the surrounding extracellular matrix to facilitate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (6): 1064–1077.
Published: 15 March 2017
... barrier, by developing specialized actin-rich membrane protrusion structures called invadopodia. The formation of invadopodia is regulated by Rho GTPases, a family of proteins that regulates the actin cytoskeleton. Here, we describe a novel role for RhoG in the regulation of invadopodia disassembly...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2017) 130 (6): 1064–1077.
Published: 15 March 2017
... barrier, by developing specialized actin-rich membrane protrusion structures called invadopodia. The formation of invadopodia is regulated by Rho GTPases, a family of proteins that regulates the actin cytoskeleton. Here, we describe a novel role for RhoG in the regulation of invadopodia disassembly...
Includes: Supplementary data