...Tomohiro Yorimitsu; Ken Sato ABSTRACT Intrinsically disordered regions (IDRs) are known to sense the positive membrane curvature of vesicles and tubules. However, whether IDRs can sense the negative curvature of their luminal surfaces remains elusive. Here, we show that IDRs direct specific...

... of the PAF1 transcription complex, to cytosolic SGs in response to arsenic stress. The hCdc73 protein possesses a long intrinsically disordered region (IDR) from amino acids 256–416, the presence of which is required for the translocation of hCdc73 to cytosolic SGs. The purified hCdc73 IDR formed droplets...

.../by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Unfolded protein response Stress response Endoplasmic reticulum Intrinsically disordered region Molecular chaperone Misfolded protein...