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Keywords: Intraflagellar transport
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Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (3): jcs253492.
Published: 11 February 2021
...Cecile Fort; Peter Collingridge; Colin Brownlee; Glen Wheeler ABSTRACT The movement of ciliary membrane proteins is directed by transient interactions with intraflagellar transport (IFT) trains. The green alga Chlamydomonas has adapted this process for gliding motility, using retrograde IFT motors...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (18): jcs248989.
Published: 23 September 2020
... at their distal end via intraflagellar transport (IFT). Immunofluorescence assays, 3D electron microscopy and live-cell imaging revealed that IFT was present in all T. brucei life cycle stages. IFT proteins are concentrated at the base, and IFT trains are located along doublets 3–4 and 7–8 and travel...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs240614.
Published: 30 March 2020
..., and its roles in cilia assembly and function. Dynein-2 Cilia Intraflagellar transport Microtubule motors Cytoplasmic dynein-2 (hereafter referred to as dynein-2) is an ATP-dependent motor protein that steps along microtubules to transport cargoes within cilia and flagella ( Box 1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (6): jcs229047.
Published: 15 March 2019
... that ubiquitylation of α-tubulin is required for the normal kinetics of axonemal disassembly. Immunoprecipitation and glutathione-S-transferase pulldown assays demonstrated that the retrograde intraflagellar transport (IFT) protein, IFT139, interacted with a variety of ubiquitylated proteins, including α-tubulin...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2019) 132 (5): jcs228296.
Published: 22 February 2019
...Diego Huet; Thierry Blisnick; Sylvie Perrot; Philippe Bastin ABSTRACT Intraflagellar transport (IFT), the movement of protein complexes responsible for the assembly of cilia and flagella, is remarkably conserved from protists to humans. However, two IFT components (IFT25 and IFT27) are missing from...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2019) 132 (5): jcs222331.
Published: 15 February 2019
... of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Highlighted Article:   Bbs4 −/− mice exhibited reduced olfactory sensory neuron cilia length/number and basal body number, as well as miscoordination of intraflagellar transport. Ectopic re-expression of BBS4 lengthened cilia...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2019) 132 (3): jcs220749.
Published: 11 February 2019
...Tyler Picariello; Jason M. Brown; Yuqing Hou; Gregory Swank; Deborah A. Cochran; Oliver D. King; Karl Lechtreck; Gregory J. Pazour; George B. Witman ABSTRACT Intraflagellar transport (IFT), which is essential for the formation and function of cilia in most organisms, is the trafficking of IFT...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2017) 130 (9): 1662–1674.
Published: 01 May 2017
...Bo Lv; Lei Wan; Michael Taschner; Xi Cheng; Esben Lorentzen; Kaiyao Huang ABSTRACT Cilia are microtubule-based organelles and perform motile, sensing and signaling functions. The assembly and maintenance of cilia depend on intraflagellar transport (IFT). Besides ciliary localization, most IFT...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2016) 129 (15): 3026–3041.
Published: 01 August 2016
...Cécile Fort; Serge Bonnefoy; Linda Kohl; Philippe Bastin ABSTRACT Intraflagellar transport (IFT) is required for construction of most cilia and flagella. Here, we used electron microscopy, immunofluorescence and live video microscopy to show that IFT is absent or arrested in the mature flagellum...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (10): 2064–2074.
Published: 15 May 2016
...Elisa Vannuccini; Eugenio Paccagnini; Francesca Cantele; Mariangela Gentile; Daniele Dini; Federica Fino; Dennis Diener; Caterina Mencarelli; Pietro Lupetti ABSTRACT Intraflagellar transport (IFT) is responsible for the bidirectional trafficking of molecular components required for the elongation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (21): 4774–4787.
Published: 01 November 2014
...David Asante; Nicola L. Stevenson; David J. Stephens ABSTRACT Cytoplasmic dynein-2 is the motor for retrograde intraflagellar transport (IFT), and mutations in dynein-2 are known to cause skeletal ciliopathies. Here, we define for the first time the composition of the human cytoplasmic dynein-2...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 1924–1937.
Published: 01 May 2014
..., a component of the intraflagellar transport (IFT) system that controls ciliogenesis, as a central regulator of TCR recycling to the immune synapse. Here, we have investigated the interplay of IFT20 with the Rab GTPase network that controls recycling. We found that IFT20 forms a complex with Rab5 and the TCR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (1): 327–338.
Published: 01 January 2013
...Johanna Buisson; Nicolas Chenouard; Thibault Lagache; Thierry Blisnick; Jean-Christophe Olivo-Marin; Philippe Bastin Summary Intraflagellar transport (IFT) is necessary for the construction of cilia and flagella. IFT proteins are concentrated at the base of the flagellum but little is known about...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (12): 2035–2044.
Published: 15 June 2010
... been implicated in cargo transport during flagellar assembly ( Scholey, 2003 ; Cole and Snell, 2009 ). The flagellar cargoes associate with intraflagellar transport (IFT) complexes that are transported from the flagellar base to the flagellar tip (anterograde) and from the flagellar tip to the base...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (4): 529–536.
Published: 15 February 2010
... as ciliopathies, result from defective cilium function has expanded interest in these structures. Among the many properties of cilia, motility and intraflagellar transport have been most extensively studied. The latter is the process by which multiprotein complexes associate with microtubule motors to transport...
Journal Articles
J Cell Sci (2009) 122 (6): 834–841.
Published: 15 March 2009
..., we demonstrate that RABL5 colocalises with intraflagellar transport (IFT) proteins at the basal body and in the flagellum matrix of the protist Trypanosoma brucei . RABL5 fused to GFP exhibits anterograde movement in the flagellum of live trypanosomes, suggesting it could be associated with IFT...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (22): 3704–3716.
Published: 15 November 2008
.... By analysis of anterograde or retrograde intraflagellar transport in IFT88 RNAi or IFT140 RNAi mutant cells, we show that elongation of the new flagellum is not required for flagellar pocket formation but is essential for its organisation, orientation and function. Transmission electron microscopy revealed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (4): 428–436.
Published: 15 February 2008
...Che-Chia Tsao; Martin A. Gorovsky Intraflagellar transport (IFT) moves multiple protein particles composed of two biochemically distinct complexes, IFT-A and IFT-B, bi-directionally within cilia and is essential for cilia assembly and maintenance. We identified an ORF from the Tetrahymena...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (20): 3653–3665.
Published: 15 October 2007
...Panteleimon Rompolas; Lotte B. Pedersen; Ramila S. Patel-King; Stephen M. King Intraflagellar transport (IFT) is the bi-directional movement of particles along the length of axonemal outer doublet microtubules and is needed for the assembly and maintenance of eukaryotic cilia and flagella...
Journal Articles
J Cell Sci (2007) 120 (4): 628–637.
Published: 15 February 2007
... of the intraflagellar transport, remains associated to the centrosome in a proliferative state. IFT88/polaris is tightly associated with the centrosome throughout the cell cycle in a microtubule- and dynein-independent manner. IFT88/polaris tetratricopeptide repeat motifs are essential for this localization...