... for endosome-to-TGN trafficking but not for other Rab7 functions. Rab7 Retromer Palmitoylation Endosomes Post-translational modifications Intracellular trafficking Retromer is an evolutionarily conserved multimeric complex first identified in the yeast Saccharomyces   cerevisiae...

.... We highlight this process in cells without microtubules and show that the recycling of Golgi factors is essential. Intracellular trafficking Microtubules Golgi In animal cells, proteins to be transported to the cell surface enter the secretory pathway at the level of the endoplasmic...

... Membrane tension Intracellular trafficking Tension-sensitivity Membrane deformation Myosin-I proteins were first discovered in lower eukaryotes ( Pollard and Korn, 1973 ), but are recognized to be widely expressed. Higher vertebrates express eight different myosin-I genes Myo1a – Myo1h...

... ). How the trafficking of autophagosomes and lysosomes is regulated as they fuse to form an autolysosome is poorly understood. Analysis of lysosomal movement has revealed a role for microtubule motor proteins in their intracellular trafficking ( Rai et al., 2013 ; Santama et al., 1998 ). Cytoplasmic...

... describe the intracellular trafficking of newly formed PrP Sc . After formation in GM1-enriched lipid microdomains at the plasma membrane, PrP Sc is rapidly internalised to early endosomes containing transferrin and cholera toxin B subunit. Following endocytosis, PrP Sc intracellular trafficking diverges...

... London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK § Author for correspondence ( j.tavare@bris.ac.uk ) 8 02 2013 © 2013. Published by The Company of Biologists Ltd 2013 Adipocyte GLUT4 Insulin Intracellular trafficking Rab14 Insulin enhances...

... and regulators involved in the spatiotemporal regulation are largely unknown. In order to identify intracellular trafficking regulators of Notch signalling, we have undertaken a tissue-specific dsRNA genetic screen of candidates potentially involved in endocytosis and recycling within the endolysosomal pathway...

... Intracellular trafficking Membrane domains Polarized sorting Epithelial cells surround and stringently regulate the contents of a variety of lumens and cavities by monitoring the bidirectional flow of water and solutes through specifically adapted apical membranes ( Martin-Belmonte and Mostov, 2008...

...V. Lila Koumandou; Mary J. Klute; Emily K. Herman; Ricardo Nunez-Miguel; Joel B. Dacks; Mark C. Field Intracellular trafficking and protein sorting are mediated by various protein complexes, with the retromer complex being primarily involved in retrograde traffic from the endosome or lysosome...

... to regulate the precise intracellular patterning of SNAP25. * Author for correspondence ( Luke.Chamberlain@ed.ac.uk ) 24 11 2010 © 2011. 2011 SNAP25 Palmitoylation Acylation Intracellular trafficking Intracellular-membrane-fusion events in eukaryotes are regulated by members...

... regulated secretion of lipoprotein lipase (LPL). However, the sorting of LPL in the trans Golgi network has not, hitherto, been understood in detail. Here, we characterize the role of SorLA (officially known as SorLA-1 or sortilin-related receptor) in the intracellular trafficking of LPL. We found that LPL...

.... * Author for correspondence ( jurrien@helix.nih.gov ) 10 11 2010 © 2011. 2011 Cytoplasmic tails Zona pellucida Oocytes Intracellular trafficking Extracellular matrix ZP2 ZP3 β-Tectorin Extracellular matrices present in the interstices of multicellular organisms form three...

... 13 9 2007 © The Company of Biologists Limited 2007 2007 Rip11 GLUT4 Glucose Insulin Intracellular trafficking AS160 Cell signalling Rab protein Scaffold protein Insulin regulates uptake of glucose into adipose tissue and muscle by promoting the rapid translocation...

...Simone Diestel; Daniel Schaefer; Harold Cremer; Brigitte Schmitz The neural cell adhesion molecule NCAM plays an important role during neural development and in the adult brain. To study the intracellular trafficking of NCAM in neurons, two major isoforms, NCAM140 or NCAM180, were expressed...

... metalloproteases Intracellular trafficking Extracellular matrix Cell invasion Degradation of the extracellular matrix (ECM) is a critical process during cell invasion in both physiological and pathological processes such as morphogenesis, differentiation, cell migration, apoptosis, tumor invasion...

... Receptor internalisation Intracellular trafficking The effects of short wavelength UV radiation on signal transduction have been intensively studied during the past decade. Exposure of mammalian cells to UV results in elevated expression of several growth-associated immediate-early genes...