.../ Summary: A novel non-canonical motif on the cytoplasmic tail of RNF13 is predicted to interact with the adaptor protein complex 1, providing molecular insights into the mechanisms altered by sorting motif variants of RNF13. RNF13 AP-1 complex AlphaFold Intracellular trafficking Endosomes...

..., intracellular trafficking and transport via extracellular vesicles. Moreover, the regulation of MMP activity is currently being rediscovered for the development of respective therapies for the treatment of cancer, as well as infectious, inflammatory and neurological diseases. In this Cell Science at a Glance...

...: Rab7 undergoes palmitoylation, a post-translational modification required for endosome-to-TGN trafficking but not for other Rab7 functions. Rab7 Retromer Palmitoylation Endosomes Post-translational modifications Intracellular trafficking Canadian Institutes of Health Research...

... National de la Recherche Scientifique 10.13039/501100004794 Agence Nationale de la Recherche 10.13039/501100001665 ANR-10-INSB-04 ANR-10-LBX-0038 ANR-10-IDEX-0001-02 PSL Intracellular trafficking Microtubules Golgi Summary: Functional maturation of Golgi elements...

... Membrane tension Intracellular trafficking Tension-sensitivity Membrane deformation National Institutes of Health 10.13039/100000002 T32 AR053461-08 P01 GM087253 R01 GM057247 Myosin-I proteins were first discovered in lower eukaryotes (Pollard and Korn, 1973), but are recognized...

... Klp98A are shown to promote vesicle formation, transport and fusion. Autophagy Intracellular trafficking Klp98A Rab14 American Heart Association 10.13039/100000968 Postdoctoral fellowship 15POST22790015 National Institutes of Health 10.13039/100000002 NIGMS GM-103833...

... describe the intracellular trafficking of newly formed PrP Sc . After formation in GM1-enriched lipid microdomains at the plasma membrane, PrP Sc is rapidly internalised to early endosomes containing transferrin and cholera toxin B subunit. Following endocytosis, PrP Sc intracellular trafficking diverges...

... London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK § Author for correspondence ([email protected]) 8 02 2013 © 2013. Published by The Company of Biologists Ltd 2013 Adipocyte GLUT4 Insulin Intracellular trafficking Rab14 Insulin enhances...

... and regulators involved in the spatiotemporal regulation are largely unknown. In order to identify intracellular trafficking regulators of Notch signalling, we have undertaken a tissue-specific dsRNA genetic screen of candidates potentially involved in endocytosis and recycling within the endolysosomal pathway...

... these membrane domains (Hancock, 2006). MARVEL motif Intracellular trafficking Membrane domains Polarized sorting © 2012. Published by The Company of Biologists Ltd 2012 12 3 2012 * Author for correspondence ([email protected]) ...

... Extracellular matrix (ECM) Guanine nucleotide exchange factor (GEF) Intracellular trafficking Lipid homeostasis Secretory pathway Tubulogenesis Tube formation in multicellular organisms depends on the ability of epithelial cells to polarize and to form basal and apical membrane compartments de novo...

...V. Lila Koumandou; Mary J. Klute; Emily K. Herman; Ricardo Nunez-Miguel; Joel B. Dacks; Mark C. Field Intracellular trafficking and protein sorting are mediated by various protein complexes, with the retromer complex being primarily involved in retrograde traffic from the endosome or lysosome...

... is dependent upon the interaction of the plasma membrane SNAREs syntaxin 1 and SNAP25 with the vesicle SNARE VAMP2 (Blasi et al., 1993 ; Gary et al., 1994 ; Sadoul et al., 1995 ; Schiavo et al., 1993 ; Sollner et al., 1993). SNAP25 Palmitoylation Acylation Intracellular trafficking...

... regulated secretion of lipoprotein lipase (LPL). However, the sorting of LPL in the trans Golgi network has not, hitherto, been understood in detail. Here, we characterize the role of SorLA (officially known as SorLA-1 or sortilin-related receptor) in the intracellular trafficking of LPL. We found that LPL...

... . * Author for correspondence ([email protected]) 10 11 2010 © 2011. 2011 Cytoplasmic tails Zona pellucida Oocytes Intracellular trafficking Extracellular matrix ZP2 ZP3 β-Tectorin Extracellular matrices present in the interstices of multicellular organisms form three...

... © The Company of Biologists Limited 2007 2007 Rip11 GLUT4 Glucose Insulin Intracellular trafficking AS160 Cell signalling Rab protein Scaffold protein Insulin regulates uptake of glucose into adipose tissue and muscle by promoting the rapid translocation of the insulin...

...Simone Diestel; Daniel Schaefer; Harold Cremer; Brigitte Schmitz The neural cell adhesion molecule NCAM plays an important role during neural development and in the adult brain. To study the intracellular trafficking of NCAM in neurons, two major isoforms, NCAM140 or NCAM180, were expressed...

...-mail: [email protected]) 24 9 2004 © The Company of Biologists Limited 2004 2004 Matrix metalloproteases Intracellular trafficking Extracellular matrix Cell invasion Degradation of the extracellular matrix (ECM) is a critical process during cell invasion in both physiological...

.... * Author for correspondence (e-mail: [email protected]) 1 11 2001 © The Company of Biologists Limited 2002 2002 UV EGF receptor Receptor internalisation Intracellular trafficking The effects of short wavelength UV radiation on signal transduction have been intensively...

... -bn upon the intracellular trafficking of basolateral and apical membrane glycoproteins at the cellular and biochemical levels in two types of cells, HT-29 G − and Caco-2, differentiated into an enterocyte-like phenotype. In HT-29 G − cells, but not in Caco-2 cells, DPP-IV and CD44 failed...