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Keywords: Intermediate filaments
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Journal Articles
J Cell Sci (2021) 134 (15): jcs250167.
Published: 03 August 2021
...Sujin Kim; Younglan Lim; So-Young Lee; Han-Na Yoon; Hayan Yi; Kwi-Hoon Jang; Nam-On Ku ABSTRACT Keratin 8 (K8) is the cytoskeletal intermediate filament protein of simple-type epithelia. Mutations in K8 predispose the affected individual and transgenic mouse to liver disease. However, the role...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (6): jcs256156.
Published: 22 March 2021
.../jbc.C200038200 Fisher , D. Z. , Chaudhary , N. and Blobel , G. ( 1986 ). cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins . Proc. Natl. Acad. Sci. USA 83 , 6450 - 6454 . 10.1073/pnas.83.17.6450 Goldman...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs250597.
Published: 05 November 2020
...Yue Zhang; Zeyu Wen; Xuemeng Shi; Yan-Jun Liu; John E. Eriksson; Yaming Jiu ABSTRACT Epidemics caused by viral infections pose a significant global threat. Cytoskeletal vimentin is a major intermediate filament (IF) protein, and is involved in numerous functions, including cell signaling...
Journal Articles
J Cell Sci (2020) 133 (14): jcs243956.
Published: 29 July 2020
...Sachiko Fujiwara; Shinji Deguchi; Thomas M. Magin ABSTRACT Keratin intermediate filament (IF) proteins constitute the major cytoskeletal components in epithelial cells. Missense mutations in keratin 5 (K5; also known as KRT5) or keratin 14 (K14; also known as KRT14), highly expressed in the basal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (9): jcs240200.
Published: 11 May 2020
... of CTP synthase filaments along the cytokeratin network to modulate enzymatic activity. CTPS filaments Intermediate filaments SNAP29 Histidine Metabolic pathways are often compartmentalized to enhance specificity and efficiency. Although membrane-bound organelles are the classical...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs228031.
Published: 16 March 2020
... sheets and developing organisms. However, these contractile networks do not work alone but in concert with other cytoarchitectural elements, including a diverse network of intermediate filaments. This Review takes a close look at the intermediate filament network and its associated intercellular...
Journal Articles
J Cell Sci (2017) 130 (20): 3437–3445.
Published: 15 October 2017
...Roy A. Quinlan; Nicole Schwarz; Reinhard Windoffer; Christine Richardson; Tim Hawkins; Joshua A. Broussard; Kathleen J. Green; Rudolf E. Leube ABSTRACT Textbook images of keratin intermediate filament (IF) networks in epithelial cells and the functional compromization of the epidermis by keratin...
Journal Articles
J Cell Sci (2017) 130 (15): 2541–2550.
Published: 01 August 2017
... 2017 http://www.biologists.com/user-licence-1-1/ Summary: K18 that is resistant to caspase digestion helps to maintain keratin filament organization and delays apoptosis, thereby protecting liver from injury. Keratin Intermediate filaments Liver Apoptosis Caspase Cell integrity...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (20): 3705–3720.
Published: 15 October 2016
... and its partner chaperone αB-crystallin associate with mitochondria–sarcoplasmic-reticulum contact sites (MAMs), stabilizing MICOS super-complexes, and thus contributing to proper mitochondrial cristae structure–function. Intermediate filaments Small heat-shock protein Cytoskeleton Heart failure...
Includes: Supplementary data
Journal Articles
In collection:
Imaging
J Cell Sci (2014) 127 (16): 3568–3577.
Published: 15 August 2014
... the control of NF-κB signaling. This kinase is post-translationally regulated through Hsp70-mediated refolding. Previous work has shown that such a chaperoning activity is specifically localized to keratin intermediate filaments. Our work was performed with the goal of identifying the molecule(s) that block...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (10): 2161–2173.
Published: 15 May 2014
...Claire L. Hyder; Glorianne Lazaro; Joanna W. Pylvänäinen; Maxwell W. G. Roberts; Susanna M. Qvarnström; John E. Eriksson ABSTRACT Nestin, an intermediate filament protein and marker of undifferentiated cells, is expressed in several cancers. Nestin is important for neuronal survival...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4195–4207.
Published: 15 September 2013
.... It acts as a critical organizer of the cytoskeletal system by tethering various intermediate filament (IF) networks through its C-terminal IF-binding domain (IFBD). Mutations affecting the IFBD cause devastating human diseases. Here, we show that serine 4642, which is located in the extreme C-terminus...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (9): 2148–2159.
Published: 01 May 2012
... filaments and microtubules in cell motility is well established, the role of intermediate filaments in this process is incompletely understood. Organization and structure of the keratin cytoskeleton, which consists of heteropolymers of at least one type 1 and one type 2 intermediate filament, are in part...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1750–1758.
Published: 01 April 2012
...Lee Wallace; Leiann Roberts-Thompson; Julia Reichelt Keratins K1 and K10 are the most abundant proteins in the upper epidermis where they polymerize to form intermediate filaments (IFs). In addition to their well-established function in providing epidermal stability, K1/K10 (i.e. the dimer between...
Journal Articles
J Cell Sci (2011) 124 (20): 3464–3476.
Published: 15 October 2011
...Gloria M. Conover; Carol C. Gregorio Desmin intermediate filaments intimately surround myofibrils in vertebrate muscle forming a mesh-like filament network. Desmin attaches to sarcomeres through its high-affinity association with nebulin, a giant F-actin binding protein that co-extends along...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (5): 755–764.
Published: 01 March 2011
...Ruben Postel; Mirjam Ketema; Ingrid Kuikman; José M. de Pereda; Arnoud Sonnenberg The outer nuclear membrane protein nesprin-3 binds the cytoskeletal linker protein plectin, which are proposed to anchor the intermediate filaments to the nuclear envelope. To investigate the function of nesprin-3...
Journal Articles
J Cell Sci (2010) 123 (15): 2543–2552.
Published: 01 August 2010
...W. Thomas Clarke; Ben Edwards; Karl J. A. McCullagh; Matthew W. Kemp; Catherine Moorwood; Diane L. Sherman; Matthew Burgess; Kay E. Davies Syncoilin is an atypical type III intermediate filament (IF) protein, which is expressed in muscle and is associated with the dystrophin-associated protein...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (21): 3851–3855.
Published: 01 November 2009
...., 2001 ); decreased threshold to oxidative injury ( Zhou et al., 2005 ); and the importance of keratins as a cytoprotective buffer by serving as a `phosphate sponge' towards stress-activated kinases ( Ku and Omary, 2006 ). Intermediate filaments (IFs), actin-containing microfilaments and microtubules...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (22): 3737–3746.
Published: 15 November 2008
...Roland Bornheim; Martin Müller; Uschi Reuter; Harald Herrmann; Heinrich Büssow; Thomas M. Magin Vimentin is the main intermediate filament (IF) protein of mesenchymal cells and tissues. Unlike other IF –/– mice, vimentin –/– mice provided no evidence of an involvement of vimentin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (19): 3384–3394.
Published: 01 October 2007
... with Sun proteins. Nuclear envelope Nesprin Sun Plectin Intermediate filaments The eukaryotic cell nucleus is surrounded by a nuclear envelope (NE), a double-layered membrane consisting of an outer nuclear membrane (ONM) and an inner nuclear membrane (INM) separated by a lumen called...
Includes: Supplementary data