...Aarthi Subramani; Maria E. L. Hite; Sarah Garcia; Jack Maxwell; Hursha Kondee; Grace E. Millican; Erin E. McClelland; Rebecca L. Seipelt-Thiemann; David E. Nelson ABSTRACT Macrophages serve as a first line of defense against microbial pathogens. Exposure to interferon-γ (IFNγ) increases interferon...

.... In this study, we first observed that knockdown of neuropilin-1 (NRP1), a co-receptor of several structurally diverse ligands, suppressed interferon-γ (IFNγ)-induced C-X-C motif chemokine 10 expression and activation of STAT1 in brain microvascular endothelial cells in a Rac1-dependent manner. Moreover...

... resistance. Here, we identify MVP as an interferon γ (IFN-γ)-inducible protein. Treatment with IFN-γ resulted in a significant upregulation of MVP promoter activity as well as mRNA and protein levels. Activation of MVP expression by IFN-γ involved transcriptional upregulation through the JAK/STAT pathway...

... 4.7 to 3.4. The tyrosine kinase blocker genistein and the protein kinase A inhibitor H-8 reduced the effect of TNFα. A combination of TNFα with interferon-γ acted synergistically on the epithelial barrier. In conclusion, TNFα impairs epithelial barrier function by altering structure and function...

... to a fluorescent punctate cell margin. Our investigations support the existence of truly separate MVEC types. * Author for correspondence 11 06 1993 28 06 1993 © 1993 by Company of Biologists 1993 microvascular endothelial cells cytoskeleton cadherins interferon-γ cell culture...

... of monocytes in the presence of IFN γ and TNF- α prevents this phenomenon. * Author for correspondence 07 08 1991 13 09 1991 © 1991 by Company of Biologists 1991 mononuclear phagocytes protein myristoylation p60 src interferon- γ tumor necrosis factor-cr...