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Keywords: Integrin-linked kinase
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Journal Articles
In collection:
J Cell Sci (2018) 131 (20): jcs221184.
Published: 26 October 2018
...Yasmin A. Kadry; Clotilde Huet-Calderwood; Bertrand Simon; David A. Calderwood ABSTRACT The integrin-associated adaptor proteins integrin-linked kinase (ILK) and kindlin-2 play central roles in integrin signaling and control of cell morphology. A direct ILK–kindlin-2 interaction is conserved across...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (19): 4308–4321.
Published: 01 October 2014
... targeting and integrin activation. We find that the integrin-linked kinase (ILK)–PINCH–parvin complex binds strongly to the kindlin-2 F2 subdomain but poorly to that of kindlin-3. Using a point-mutated kindlin-2, we establish that efficient kindlin-2-mediated integrin activation and FA targeting require...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4099–4107.
Published: 15 September 2013
... the role of a major FA component, namely, integrin-linked kinase (ILK), in adhesion formation. We show here that ILK plays a key role in the formation of focal complexes, early forms of integrin adhesions, and confirm its involvement in the assembly of fibronectin-bound fibrillar adhesions. Examination...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (13): 3185–3194.
Published: 01 July 2012
...Maria C. Elias; Stephen M. Pronovost; Kinley J. Cahill; Mary C. Beckerle; Julie L. Kadrmas Summary PINCH, integrin-linked kinase (ILK) and Ras suppressor-1 (RSU-1) are molecular scaffolding proteins that form a physical complex downstream of integrins, and have overlapping roles in cellular...
Journal Articles
J Cell Sci (2010) 123 (5): 747–755.
Published: 01 March 2010
... the macromolecular events involved in signal transduction processes. In this study, functional molecular imaging using a luciferase-based complementation method demonstrated how the integrin-linked kinase (ILK)-mediated protein complex controls downstream signals. The luciferase complementation assay showed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (19): 3121–3132.
Published: 01 October 2008
...Paul C. McDonald; Andrew B. Fielding; Shoukat Dedhar Integrin-linked kinase (ILK) is a multifunctional intracellular effector of cell-matrix interactions and regulates many cellular processes, including growth, proliferation, survival, differentiation, migration, invasion and angiogenesis. The use...
Journal Articles
J Cell Sci (2004) 117 (19): 4559–4569.
Published: 01 September 2004
...Valérie Vouret-Craviari; Etienne Boulter; Dominique Grall; Cédric Matthews; Ellen Van Obberghen-Schilling Integrins play a key role in regulating endothelial cell survival, migration and differentiated function during angiogenic blood-vessel remodeling. Integrin-linked kinase (ILK...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (24): 4777–4786.
Published: 15 December 2002
...Yongjun Zhang; Ka Chen; Yizeng Tu; Algirdas Velyvis; Yanwu Yang; Jun Qin; Chuanyue Wu PINCH, integrin-linked kinase (ILK) and calponin homology-containing ILK-binding protein (CH-ILKBP) form a ternary complex that plays crucial roles at cell-extracellular matrix adhesion sites. To understand...