... is required for β 2 integrin activation, which is consistent with previous studies (Fan and Ley, 2015 ; Zarbock et al., 2007). Furthermore, the anti-E-selectin mAb ES1 (Fab) totally abolished adhesion (Fig. 2 C), confirming that E-selectin binding is required for β 2 integrins in Ca 2+ /Mg 2+ to interact...

... filaments underneath the plasma membrane might provide integrin-binding sites to mediate integrin clustering, which in turn can enhance integrin–ligand interaction. Integrin Vimentin Integrin activation H-Ras Talin National Research Foundation of Korea (NRF) and funded by the Ministry...

...-70-like adaptor of T cells (SLAT). SLAT Def6 Rap1 Integrin activation T cell-adhesion Inside-out signaling Immunological synapse An efficient adaptive immune response depends on the capacity of leukocytes, especially T cells, to quickly recirculate through blood and lymph...

...Clotilde Huet-Calderwood; Nina N. Brahme; Nikit Kumar; Amy L. Stiegler; Srikala Raghavan; Titus J. Boggon; David A. Calderwood ABSTRACT Kindlins are essential FERM-domain-containing focal adhesion (FA) proteins required for proper integrin activation and signaling. Despite the widely accepted...

... that allows relaxation of the α1/α1′-helix in the resting state and transmission of bidirectional conformational signals by helix unbending upon integrin activation. * Present address: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China...

... of the scaffold protein, talin, to the cytoplasmic tail of β-integrin causes a conformational change of the extracellular domains of the integrin heterodimer, thus allowing high-affinity binding of ECM ligands. This essential process is called integrin activation. Here we report that the Z-band alternatively...

..., respectively. An adaptation of the assay revealed the agonistic activity of these small molecules, thus demonstrating that these compounds may induce secondary effects in vivo via integrin activation. This study provides insight into the dependence of the activity of small molecule anti-integrin compounds upon...

... 1 integrins, and that this enzyme may be required for upregulation of cell-substrate and cell-cell adhesion. *Author for correspondence (e-mail: [email protected]) 1 6 2001 © The Company of Biologists Limited 2001 2001 Integrin activation Cell-cell adhesion cAMP PKA F...

...) * Both authors contributed equally to this work 24 01 2001 © 2001 by Company of Biologists 2001 Integrin αvβ3 Vitronectin receptor Affinity modulation Integrin activation Soluble recombinant cell adhesion molecule Cyclo-RGD Integrins are a family of αβ-heterodimeric...