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Keywords: Integrin activation
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Journal Articles
In collection:
Adhesion
J Cell Sci (2021) 134 (18): jcs258046.
Published: 23 September 2021
...-zone channels and measured neutrophil rolling velocity as a proxy for integrin activation. We demonstrated that the product of coating concentration and zone length is a single stimulation-dose variable for α L β 2 activation. We used the Hill equation to characterize these dose response curves...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2016) 129 (10): 2030–2042.
Published: 15 May 2016
... first investigated the relationship between the H-Ras signaling and the well-known talin-mediated integrin activation process to gather information on the unidentified effector of H-Ras signaling. Because unmasking of the integrin-binding site in talin is known to be required for talin-induced integrin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4341–4352.
Published: 01 December 2015
... Kinashi , T. ( 2005 ). Intracellular signalling controlling integrin activation in lymphocytes . Nat. Rev. Immunol.   5 , 546 - 559 . 10.1038/nri1646 Kliche , S. , Breitling , D. , Togni , M. , Pusch , R. , Heuer , K. , Wang , X. , Freund , C. , Kasirer-Friede...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (19): 4308–4321.
Published: 01 October 2014
...Clotilde Huet-Calderwood; Nina N. Brahme; Nikit Kumar; Amy L. Stiegler; Srikala Raghavan; Titus J. Boggon; David A. Calderwood ABSTRACT Kindlins are essential FERM-domain-containing focal adhesion (FA) proteins required for proper integrin activation and signaling. Despite the widely accepted...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5735–5747.
Published: 15 December 2013
... that allows relaxation of the α1/α1′-helix in the resting state and transmission of bidirectional conformational signals by helix unbending upon integrin activation. * Present address: College of Animal Science and Veterinary Medicine, Qingdao Agricultural University, Qingdao 266109, China...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5647–5657.
Published: 01 December 2012
... of the scaffold protein, talin, to the cytoplasmic tail of β-integrin causes a conformational change of the extracellular domains of the integrin heterodimer, thus allowing high-affinity binding of ECM ligands. This essential process is called integrin activation. Here we report that the Z-band alternatively...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (3): 265–271.
Published: 01 February 2008
..., respectively. An adaptation of the assay revealed the agonistic activity of these small molecules, thus demonstrating that these compounds may induce secondary effects in vivo via integrin activation. This study provides insight into the dependence of the activity of small molecule anti-integrin compounds upon...
Includes: Supplementary data
Journal Articles
J Cell Sci (2001) 114 (18): 3265–3272.
Published: 15 September 2001
... 1 integrins, and that this enzyme may be required for upregulation of cell-substrate and cell-cell adhesion. *Author for correspondence (e-mail: akiyama@niehs.nih.gov ) 1 6 2001 © The Company of Biologists Limited 2001 2001 Integrin activation Cell-cell adhesion cAMP PKA...