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Keywords: Insulin-degrading enzyme
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Journal Articles
Valérie Vingtdeux, Pallavi Chandakkar, Haitian Zhao, Lionel Blanc, Santiago Ruiz, Philippe Marambaud
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (13): 2330–2338.
Published: 1 July 2015
... for the Aβ-lowering effect of CALHM1. Aβ level reduction by CALHM1 could be explained by an increase in extracellular Aβ degradation by insulin-degrading enzyme (IDE), extracellular secretion of which was strongly potentiated by CALHM1 activation. Importantly, Calhm1 knockout in mice reduced IDE enzymatic...