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Keywords: Insulin secretion
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J Cell Sci (2022) 135 (5): jcs259073.
Published: 16 December 2021
... at these locations. In pancreatic β-cells, both lipid and Ca 2+ signaling are essential for insulin secretion. The recently characterized lipid transfer protein TMEM24 (also known as C2CD2L) dynamically localizes to ER–PM contact sites and provides phosphatidylinositol, a precursor of phosphatidylinositol-4...
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J Cell Sci (2019) 132 (13): jcs231373.
Published: 1 July 2019
... biogenesis in some cell types, including the pancreatic islet β-cell, though the mechanisms are poorly understood. Here, we demonstrate a critical role for CgB in regulating secretory granule trafficking in the β-cell. Loss of CgB impairs glucose-stimulated insulin secretion, impedes proinsulin processing...
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Autophagy
J Cell Sci (2018) 131 (15): jcs212969.
Published: 6 August 2018
... markedly stimulated autophagy in an adenosine A 1 receptor-dependent manner. High-concentration adenosine increased insulin secretion in a manner sensitive to treatment with the autophagy inducer Tat-beclin1, and inhibition of autophagy augmented secretion. In conclusion, high concentrations of AICAR...
Includes: Supplementary data
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J Cell Sci (2016) 129 (12): 2462–2471.
Published: 15 June 2016
... studies of imbalanced hormone secretion during type 2 diabetes progression. Insulin secretion Glucagon secretion Diabetes α-cell mass β-cell mass Islets National Natural Science Foundation of China 10.13039/501100001809 81222020 31221002 31327901 31570839 31301186 31471034...
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J Cell Sci (2008) 121 (3): 391–403.
Published: 1 February 2008
... as a conformational switch to regulate exocytosis. * Author for correspondence (e-mail: [email protected] ) 1 11 2007 © The Company of Biologists Limited 2008 2008 Cell polarity IQGAP1 Insulin secretion Polarized cell growth is essential for specialized cellular functions...
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J Cell Sci (2004) 117 (15): 3119–3127.
Published: 1 July 2004
...., Meda, P., Li, G., Halban, P. A. and Wollheim, C. B. ( 1992 ). Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130 , 167 -178. Brose, N. and Rosenmund, C. ( 2002 ). Move over protein kinase C, you've got company: alternative cellular...
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J Cell Sci (2001) 114 (11): 2179–2186.
Published: 1 June 2001
... 3+ and 2-aminoethoxydiphenyl borate but neither of these agents discriminated between store-operated and voltage-dependent entry. The finely tuned regulation of the store-operated mechanisms in the β-cell has direct implications for the control of membrane potential and insulin secretion...
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