...Ivar Noordstra; Cyntha M. van den Berg; Fransje W. J. Boot; Eugene A. Katrukha; Ka Lou Yu; Roderick P. Tas; Sybren Portegies; Bastiaan J. Viergever; Esther de Graaff; Casper C. Hoogenraad; Eelco J. P. de Koning; Françoise Carlotti; Lukas C. Kapitein; Anna Akhmanova ABSTRACT Insulin secretion...

... at these locations. In pancreatic β-cells, both lipid and Ca 2+ signaling are essential for insulin secretion. The recently characterized lipid transfer protein TMEM24 (also known as C2CD2L) dynamically localizes to ER–PM contact sites and provides phosphatidylinositol, a precursor of phosphatidylinositol-4...

...)-derived fetuin-A (also known as AHSG) in macrophage polarization and decipher the effect of M1 type pro-inflammatory macrophages in commanding over insulin secretion. MIN6 and islet-derived fetuin-A induced expression of the M1 type macrophage markers Emr1 (also known as Adgre1 ), Cd68 and CD11c ( Itgax...

... biogenesis in some cell types, including the pancreatic islet β-cell, though the mechanisms are poorly understood. Here, we demonstrate a critical role for CgB in regulating secretory granule trafficking in the β-cell. Loss of CgB impairs glucose-stimulated insulin secretion, impedes proinsulin processing...

... markedly stimulated autophagy in an adenosine A 1 receptor-dependent manner. High-concentration adenosine increased insulin secretion in a manner sensitive to treatment with the autophagy inducer Tat-beclin1, and inhibition of autophagy augmented secretion. In conclusion, high concentrations of AICAR...

... studies of imbalanced hormone secretion during type 2 diabetes progression. Insulin secretion Glucagon secretion Diabetes α-cell mass β-cell mass Islets The blood glucose level is tightly regulated under normal conditions, and its dysregulation leads to diabetes mellitus, which affects...

... as a conformational switch to regulate exocytosis. * Author for correspondence (e-mail: mo28@cornell.edu ) 1 11 2007 © The Company of Biologists Limited 2008 2008 Cell polarity IQGAP1 Insulin secretion Polarized cell growth is essential for specialized cellular functions...

... of insulin from isolated islets in response to glucose or depolarizing stimulation was impaired. These results suggest that the a 3 isoform of V-ATPase has a regulatory function in the exocytosis of insulin secretion. Antibodies against subunit a isoforms were prepared as described previously ( Toyomura...

...Fabrice Chimienti; Séverine Devergnas; François Pattou; Frans Schuit; Rachel Garcia-Cuenca; Brigitte Vandewalle; Julie Kerr-Conte; Leentje Van Lommel; Didier Grunwald; Alain Favier; Michel Seve Insulin-secreting pancreatic beta cells are exceptionally rich in zinc. In these cells, zinc...

...Alejandra Tomas; Barbara Yermen; Le Min; Jeffrey E. Pessin; Philippe A. Halban We have previously isolated two MIN6 β-cell sublines, B1, highly responsive to glucose-stimulated insulin secretion, and C3, markedly refractory (Lilla, V., Webb, G., Rickenbach, K., Maturana, A., Steiner, D. F., Halban...

...., Meda, P., Li, G., Halban, P. A. and Wollheim, C. B. ( 1992 ). Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130 , 167 -178. Brose, N. and Rosenmund, C. ( 2002 ). Move over protein kinase C, you've got company: alternative cellular...

... 3+ and 2-aminoethoxydiphenyl borate but neither of these agents discriminated between store-operated and voltage-dependent entry. The finely tuned regulation of the store-operated mechanisms in the β-cell has direct implications for the control of membrane potential and insulin secretion...