...Victoria L. Tokarz; Sivakami Mylvaganam; Amira Klip ABSTRACT Skeletal muscle insulin resistance, a major contributor to type 2 diabetes, is linked to the consumption of saturated fats. This insulin resistance arises from failure of insulin-induced translocation of glucose transporter type 4 (GLUT4...

... protein-dependent modulation of PI3K signalling . Sci. Rep. 7 , 5408 . 10.1038/s41598-017-05908-7 Bindlish , S. , Presswala , L. S. and Schwartz , F. (2015). Lipodystrophy: syndrome of severe insulin resistance . Postgrad. Med. 127 , 511 - 516 . 10.1080...

...) to investigate the characteristics of plasma-membrane-fused GLUT4 at the single-molecule level, we have demonstrated that insulin and insulin resistance regulate the spatial organization of GLUT4 in adipocytes. Stimulation with insulin shifted the balance of GLUT4 on the plasma membrane toward a more dispersed...

... differentiation, insulin resistance, lipid storage and obesity, but the underlying cellular defects caused by altering lipin levels are not known. Here, we identify the Caenorhabditis elegans lipin homolog (LPIN-1) and examine its affect on NE dynamics. We find that downregulating LPIN-1 by RNAi results...