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Keywords: Insulin
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Journal Articles
J Cell Sci (2020) 133 (19): jcs235838.
Published: 12 October 2020
...Peilang Yang; Xiqiao Wang; Di Wang; Yan Shi; Meng Zhang; Tianyi Yu; Dan Liu; Min Gao; Xiong Zhang; Yan Liu ABSTRACT Besides regulating glucose levels, insulin has been reported to participate actively in many other functions, including modulating inflammatory reactions. In this study we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs236794.
Published: 30 March 2020
...Wei Ma; Jenny Chang; Jason Tong; Uda Ho; Belinda Yau; Melkam A. Kebede; Peter Thorn ABSTRACT F-actin dynamics are known to control insulin secretion, but the point of intersection with the stimulus-secretion cascade is unknown. Here, using multiphoton imaging of β cells isolated from Lifeact-GFP...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2019) 132 (9): jcs228544.
Published: 30 April 2019
...Nadine Griesche; Gonzalo Sanchez; Cedric Hermans; Olof Idevall-Hagren ABSTRACT Mitochondria play an essential role in regulating insulin secretion from beta cells by providing the ATP needed for the membrane depolarization that results in voltage-dependent Ca 2+ influx and subsequent insulin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (17): jcs216127.
Published: 07 September 2018
... accumulation of enlarged autophagic vesicles resulting in part from a failure to deliver lysosomal hydrolases, rendering autolysosomes with a reduced degradative capacity and impaired turnover. Additionally, Rab6-deficient cells are reduced in size and display defective insulin–TOR signaling as a result of mis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (16): 2757–2766.
Published: 15 August 2017
... discern Akt localisation, yet it has not been clear how well these tools recapitulate the behaviour of endogenous Akt proteins. Here, we observed that fusion of eGFP to Akt2 impaired both its insulin-stimulated plasma membrane recruitment and its phosphorylation. Endogenous-like responses were restored by...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (3): 541–550.
Published: 01 February 2017
... glucose-stimulated insulin secretion. Although knockdown of any component of the ternary complex markedly inhibits insulin secretion, only knockdown of Rab2a or Noc2, and not that of Rab27a, impairs cargo processing from proinsulin to insulin. These results suggest that the dual effector, Noc2, regulates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 143–151.
Published: 01 January 2017
...: apical, lateral and basal. Insulin Polarity Islet Diabetes β-Cell Cell polarity is established in response to external cues, and drives cell orientation and regional specialisations that are essential for cell function ( Roignot et al., 2013 ; Yu et al., 2005 ). Apical-basal polarity...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (11): 2273–2284.
Published: 01 June 2016
... adipocytes. In contrast, the same loop of GLUT1 was without effect. The reporter molecules to which the first loop of GLUT4 was fused localized, unlike GLUT4, to the trans-Golgi network (TGN), possibly explaining why these molecules did not respond to insulin. The retention induced by the GLUT4 loop was...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (3): 637–649.
Published: 01 February 2016
... TBC1D10A) and identified the Arf6 guanine-nucleotide-exchange factor (GEF) ARNO (also known as CYTH2) in pancreatic β-cells. We found that the insulin secretagogue glucose promotes phosphatidylinositol (3,4,5)-trisphosphate (PIP 3 ) generation through phosphoinositide 3-kinase (PI3K), thereby recruiting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (9): 1931–1941.
Published: 01 May 2013
...Sam E. Reed; Lorna R. Hodgson; Shuang Song; Margaret T. May; Eoin E. Kelly; Mary W. McCaffrey; Cynthia C. Mastick; Paul Verkade; Jeremy M. Tavaré Summary Insulin enhances the uptake of glucose into adipocytes and muscle cells by promoting the redistribution of the glucose transporter isoform 4...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (9): 1962–1968.
Published: 01 May 2013
... interacts with the ER chaperone GRP78/BiP, the ER-associated degradation (ERAD) machinery and with misfolded proinsulin. Unexpectedly, knockdown of SDF2L1 in INS-1 (insulin 2 C96Y-GFP) cells increased the degradation kinetics of mutant proinsulin, suggesting that SDF2L1 regulates substrate availability for...
Journal Articles
J Cell Sci (2012) 125 (23): 5597–5608.
Published: 01 December 2012
.... Published by The Company of Biologists Ltd 2012 Metabolism Stem cells ESCs Reprogramming iPSCs HSCs NSCs AMPK FOXO mTOR SIRT1 Insulin Hypoxia Aging Stem cells serve as the origin for all tissues during embryonic and postnatal development, and contribute to tissue homeostasis and...
Journal Articles
J Cell Sci (2011) 124 (5): 801–811.
Published: 01 March 2011
...Jimena Giudice; Federico Coluccio Leskow; Donna J. Arndt-Jovin; Thomas M. Jovin; Elizabeth A. Jares-Erijman Insulin signaling comprises a complex cascade of events, playing a key role in the regulation of glucose metabolism and cellular growth. Impaired response to insulin is the hallmark of...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2010) 123 (1): 13–22.
Published: 01 January 2010
... is recruited to the plasma membrane in response to insulin and is targeted to substrates by forming transient holoenzyme complexes that have different specificities. Cytosolic O -GlcNAcylation is important for the proper transduction of signaling cascades such as the NFκB pathway, whereas nuclear O...
Journal Articles
J Cell Sci (2009) 122 (6): 775–779.
Published: 15 March 2009
... this affects native currents and cellular excitability remains to be determined. The voltage-dependent K + (Kv) channel Kv2.1 regulates pancreatic β-cell excitability and insulin secretion. We found that YFP-tagged SUMO1 (SUMO1-YFP) can be immunoprecipitated with Kv2.1 when these two proteins are...
Journal Articles
J Cell Sci (2009) 122 (5): 611–624.
Published: 01 March 2009
... C. elegans mks / mksr mutants do not display overt defects in ciliary structure, intraflagellar transport or chemosensation. However, we find genetic interactions between all double mks / mksr mutant combinations, manifesting as an increased lifespan phenotype, which is due to abnormal insulin–IGF-I...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (5): 727–734.
Published: 01 March 2009
... limiting external membrane surface of sarcolemma and transverse-tubules in response to insulin, contraction or activators of energy-status signalling, including hypoxia. HA-GLUT4-GFP is largely excluded from the sarcolemma and transverse-tubule membrane of cardiomyocytes under basal conditions, but is...
Journal Articles
J Cell Sci (2008) 121 (20): 3383–3392.
Published: 15 October 2008
...Natalia Vereshchagina; Marie-Christine Ramel; Emmanuelle Bitoun; Clive Wilson Inappropriate regulation of the PI3-kinase/PTEN/Akt kinase-signalling cassette, a key downstream target of insulin/insulin-like growth factor signalling (IIS), is associated with several major human diseases such as...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (18): 3092–3098.
Published: 15 September 2008
... directly bound GDP-Rab27a through its β-propeller structure. The most important insulin secretagogue glucose promptly shifted Rab27a from the GTP- to GDP-bound form. Knockdown of coronin 3 by RNAi resulted in the inhibition of phogrin (an insulin-granule-associated protein) internalization and the uptake...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (8): 1243–1251.
Published: 15 April 2008
...Robert T. Watson; Jeffrey E. Pessin Insulin recruits two transmembrane proteins, GLUT4 and IRAP, to the plasma membrane of muscle cells and adipocytes. The subcellular trafficking and localization of GLUT4, and to a lesser extent IRAP, have been intensely studied, yet the molecular mechanisms...