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Keywords: Inflammation
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Journal Articles
J Cell Sci (2022) 135 (16): jcs260096.
Published: 19 August 2022
... and pathogen survival. AP-1 transcription factor Inflammation Microbiology PTMs SUMOylation Salmonella Ministry of Education, India http://dx.doi.org/10.13039/501100004541 STARS/APR2019/BS/730/FS Indian Council of Medical Research http://dx.doi.org/10.13039/501100001411...
Includes: Supplementary data
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Polarity
J Cell Sci (2021) 134 (24): jcs259161.
Published: 22 December 2021
... cooperate in kidney collecting duct development, we deleted α3 and α6 in the developing ureteric bud. The collecting system of the double knockout phenocopied the α3 integrin conditional knockout. However, with age, the mice developed severe inflammation and fibrosis around the collecting ducts, resulting...
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Cell Migration
J Cell Sci (2021) 134 (21): jcs258690.
Published: 4 November 2021
... , H. ( 2000 ). Shear stress affects migration behavior of polymorphonuclear cells arrested on endothelium . Cell. Immunol. 203 , 39 - 46 . 10.1006/cimm.2000.1671 Lim , S. and Park , S. ( 2014 ). Role of vascular smooth muscle cell in the inflammation of atherosclerosis...
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Membrane Trafficking
J Cell Sci (2021) 134 (1): jcs250951.
Published: 8 January 2021
.... and Schmid , J. A. ( 2013 ). The complexity of NF-κB signaling in inflammation and cancer . Mol. Cancer 12 , 86 . 10.1186/1476-4598-12-86 Hurley , J. H. ( 2015 ). ESCRTs are everywhere . EMBO J. 34 , 2398 - 2407 . 10.15252/embj.201592484 Keestra-Gounder , A. M...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs248864.
Published: 23 December 2020
... by IL-4 and mediates macrophage fusion for the formation of multinucleated giant cells. IL-4 Macrophage Monocyte Inflammation Mass spectrometry Foreign body giant cells Multinucleated giant cells (MGCs) are polykaryons of monocytic origin that are spatially associated with foreign...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (23): jcs248344.
Published: 3 December 2020
... a CARD (ASC; also known as PYCARD), caspase-1 and probably other regulatory proteins, also bears considerable potential for detrimental inflammation, as observed in human conditions such as gout, heart attack, stroke and Alzheimer's disease. Thus, multi-layered regulatory networks are required to ensure...
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Mitochondria
J Cell Sci (2020) 133 (22): jcs247353.
Published: 30 November 2020
... chondrocytes through a mechanism that involves reactive oxygen species-dependent activation of the JNK/AP1 pathway. Osteoarthritis Chondrocytes Redox Inflammation JNK cFos AP1 Mitochondria are complex organelles and the site of oxidative phosphorylation and cellular energy production under...
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Cilia and Flagella
J Cell Sci (2020) 133 (13): jcs239871.
Published: 8 July 2020
... of ciliary intraflagellar transport (IFT), altered the cell response to IL-1β, supporting a putative link emerging between cilia and inflammation. Here, we show that IFT88 depletion affects specific cytokine-regulated behaviours, changing cytosolic NFκB translocation dynamics but leaving MAPK signalling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs239194.
Published: 30 December 2019
...Lin Luo; Richard M. Lucas; Liping Liu; Jennifer L. Stow; Ana-Maria Lennon-Duménil ABSTRACT Toll-like receptors (TLRs) are danger-sensing receptors that typically propagate self-limiting inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or disease settings...
Journal Articles
J Cell Sci (2020) 133 (5): jcs236588.
Published: 5 December 2019
...Jiarui Bi; Leeni Koivisto; Jiayin Dai; Deshu Zhuang; Guoqiao Jiang; Milla Larjava; Ya Shen; Liangjia Bi; Fang Liu; Markus Haapasalo; Lari Häkkinen; Hannu Larjava; Ana-Maria Lennon-Duménil ABSTRACT In periodontal disease (PD), bacterial biofilms cause gingival inflammation, leading to bone loss...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs236075.
Published: 26 September 2019
...David B. Gurevich; Kathryn E. French; John D. Collin; Stephen J. Cross; Paul Martin; Ana-Maria Lennon-Duménil ABSTRACT Implanting biomaterials in tissues leads to inflammation and a foreign body response (FBR), which can result in rejection. Here, we live image the FBR triggered by surgical suture...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (17): jcs227728.
Published: 5 September 2019
..., junctional proteins and, consequently, endothelial barrier function. In this Review, we discuss the emerging role of ubiquitylation and deubiquitylation events in endothelial integrity and inflammation. The picture that emerges is one of increasing complexity, which is both fascinating and promising given...
Journal Articles
J Cell Sci (2019) 132 (7): jcs225615.
Published: 3 April 2019
... of TNF receptor superfamily members, such as the lymphotoxin-β receptor (LTβR), and is implicated in pathological angiogenesis associated with chronic inflammation and cancer. Here, we identify a previously unrecognized role of the LTβR–NIK axis during inflammatory activation of human endothelial cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (1): jcs220228.
Published: 2 January 2019
...-specific receptor that stabilizes the vasculature in pathological angiogenesis. Although Robo4 has been shown to suppress vascular hyperpermeability induced by vascular endothelial growth factor (VEGF) in angiogenesis, the role of Robo4 in inflammation is poorly understood. In this study, we investigated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (11): jcs213967.
Published: 5 June 2018
...Yongqiang Wang; Matthew Galli; Alexandra Shade Silver; Wilson Lee; Yushan Song; Yixue Mei; Carly Bachus; Michael Glogauer; Christopher A. McCulloch ABSTRACT Adseverin is an actin-binding protein involved in osteoclastogenesis, but its role in inflammation-induced bone loss is not well-defined. Here...
Journal Articles
J Cell Sci (2018) 131 (3): jcs211151.
Published: 30 January 2018
...Shunyao Xu; Zhen Zhou; Hao Li; Ziying Liu; Xiaojun Pan; Fen Wang; Yueyue Huang; Xiaogang Li; Yunbei Xiao; Jingye Pan; Cong Wang; Dequan Li ABSTRACT Sepsis is an aggressive and life-threatening systemic inflammatory response with a high mortality. Inflammation and coagulation play crucial roles...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (1): jcs205575.
Published: 10 January 2018
...Alexander Buffone, Jr; Nicholas R. Anderson; Daniel A. Hammer ABSTRACT The recruitment of immune cells during inflammation is regulated by a multi-step cascade of cell rolling, activation, adhesion and transmigration through the endothelial barrier. Similarly, hematopoietic stem and progenitor...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (1): 190–202.
Published: 1 January 2017
...) drive cancer progression and promote inflammation. Here, we show that the non-polarized breast cancer cell line T4-2 generates significantly higher ROS levels than polarized S1 and T4R cells in three-dimensional (3D) culture, accompanied by induction of the nuclear factor κB (NF-κB) pathway and cytokine...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 9–16.
Published: 1 January 2016
... are subverted during inflammation, cancer and other pathologies. Abl kinases can be activated by multiple stimuli leading to cytoskeletal reorganization required for cell morphogenesis, motility, adhesion and polarity. Depending on the cellular context, Abl kinases regulate cell survival and proliferation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (1): 65–79.
Published: 1 January 2016
... and phosphatidylserine exposure by PC12 cells, resulting in their cell death by phagocytosis. Phagocytosis Neuroinflammation Cancer Phosphatidylserine Inflammation Caspase Apoptosis was originally characterised as a form of cell death accompanied by nuclear condensation, cell shrinkage and subsequent...
Includes: Supplementary data