.... and Ciofani , M. ( 2017 ). JunB promotes Th17 cell identity and restrains alternative CD4(+) T-cell programs during inflammation . Nat. Commun. 8 , 301 . 10.1038/s41467-017-00380-3 Chen , L. C. , Chen , B. K. and Chang , W. C. ( 2005 ). Activating protein 1-mediated...

... This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Cancer Inflammation...

.... Summary: Disturbed flow is a key factor in promoting endothelial dysfunction. Frizzled-4 mediates the pro-inflammatory and barrier-disrupting effects of disturbed flow in endothelial cells via a WNT5A- and β-catenin-dependent mechanism. Mechanotransduction Inflammation Orbital shaker...

... inflammation but not cell death. However, under neuroinflammatory conditions, TNF and CaMKII activation coordinately hyper-activate TAK1, resulting in necroptosis. Neuroinflammation is associated with many neurodegenerative diseases...

... overview of recent advances in the molecular regulation of necroptosis and its roles in pathogen defense and tissue homeostasis. Necroptosis RIPK1 RIPK3 ZBP1 TRIF RHIM Inflammation TNF Necrosis Cancer National Institutes of Health http://dx.doi.org/10.13039/100000002 AI148302...

... and pathogen survival. AP-1 transcription factor Inflammation Microbiology PTMs SUMOylation Salmonella Ministry of Education, India http://dx.doi.org/10.13039/501100004541 STARS/APR2019/BS/730/FS Indian Council of Medical Research http://dx.doi.org/10.13039/501100001411...

... cooperate in kidney collecting duct development, we deleted α3 and α6 in the developing ureteric bud. The collecting system of the double knockout phenocopied the α3 integrin conditional knockout. However, with age, the mice developed severe inflammation and fibrosis around the collecting ducts, resulting...

... , H. ( 2000 ). Shear stress affects migration behavior of polymorphonuclear cells arrested on endothelium . Cell. Immunol. 203 , 39 - 46 . 10.1006/cimm.2000.1671 Lim , S. and Park , S. ( 2014 ). Role of vascular smooth muscle cell in the inflammation of atherosclerosis...

... signaling in inflammation and cancer . Mol. Cancer 12 , 86 . 10.1186/1476-4598-12-86 Hurley , J. H. ( 2015 ). ESCRTs are everywhere . EMBO J. 34 , 2398 - 2407 . 10.15252/embj.201592484 Keestra-Gounder , A. M. , Byndloss , M. X. , Seyffert , N. , Young , B. M...

... by IL-4 and mediates macrophage fusion for the formation of multinucleated giant cells. IL-4 Macrophage Monocyte Inflammation Mass spectrometry Foreign body giant cells Multinucleated giant cells (MGCs) are polykaryons of monocytic origin that are spatially associated with foreign...

... a CARD (ASC; also known as PYCARD), caspase-1 and probably other regulatory proteins, also bears considerable potential for detrimental inflammation, as observed in human conditions such as gout, heart attack, stroke and Alzheimer's disease. Thus, multi-layered regulatory networks are required to ensure...

... chondrocytes through a mechanism that involves reactive oxygen species-dependent activation of the JNK/AP1 pathway. Osteoarthritis Chondrocytes Redox Inflammation JNK cFos AP1 Mitochondria are complex organelles and the site of oxidative phosphorylation and cellular energy production under...

... of ciliary intraflagellar transport (IFT), altered the cell response to IL-1β, supporting a putative link emerging between cilia and inflammation. Here, we show that IFT88 depletion affects specific cytokine-regulated behaviours, changing cytosolic NFκB translocation dynamics but leaving MAPK signalling...

...Lin Luo; Richard M. Lucas; Liping Liu; Jennifer L. Stow; Ana-Maria Lennon-Duménil ABSTRACT Toll-like receptors (TLRs) are danger-sensing receptors that typically propagate self-limiting inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or disease settings...

...Jiarui Bi; Leeni Koivisto; Jiayin Dai; Deshu Zhuang; Guoqiao Jiang; Milla Larjava; Ya Shen; Liangjia Bi; Fang Liu; Markus Haapasalo; Lari Häkkinen; Hannu Larjava; Ana-Maria Lennon-Duménil ABSTRACT In periodontal disease (PD), bacterial biofilms cause gingival inflammation, leading to bone loss...

...David B. Gurevich; Kathryn E. French; John D. Collin; Stephen J. Cross; Paul Martin; Ana-Maria Lennon-Duménil ABSTRACT Implanting biomaterials in tissues leads to inflammation and a foreign body response (FBR), which can result in rejection. Here, we live image the FBR triggered by surgical suture...

..., junctional proteins and, consequently, endothelial barrier function. In this Review, we discuss the emerging role of ubiquitylation and deubiquitylation events in endothelial integrity and inflammation. The picture that emerges is one of increasing complexity, which is both fascinating and promising given...

... of TNF receptor superfamily members, such as the lymphotoxin-β receptor (LTβR), and is implicated in pathological angiogenesis associated with chronic inflammation and cancer. Here, we identify a previously unrecognized role of the LTβR–NIK axis during inflammatory activation of human endothelial cells...

...-specific receptor that stabilizes the vasculature in pathological angiogenesis. Although Robo4 has been shown to suppress vascular hyperpermeability induced by vascular endothelial growth factor (VEGF) in angiogenesis, the role of Robo4 in inflammation is poorly understood. In this study, we investigated...

...Yongqiang Wang; Matthew Galli; Alexandra Shade Silver; Wilson Lee; Yushan Song; Yixue Mei; Carly Bachus; Michael Glogauer; Christopher A. McCulloch ABSTRACT Adseverin is an actin-binding protein involved in osteoclastogenesis, but its role in inflammation-induced bone loss is not well-defined. Here...