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Keywords: Inflammation
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Journal Articles
J Cell Sci (2023) 136 (23): jcs261152.
Published: 15 December 2023
... driving altered healing responses in vivo . Together, these data suggest an important role for AP-1 signaling and inflammation in modulating fibroblast stress responses following MI, which could ultimately influence regenerative outcomes. Many studies from the past few decades have identified single...
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J Cell Sci (2022) 135 (17): jcs260091.
Published: 13 September 2022
... overview of recent advances in the molecular regulation of necroptosis and its roles in pathogen defense and tissue homeostasis. Necroptosis RIPK1 RIPK3 ZBP1 TRIF RHIM Inflammation TNF Necrosis Cancer National Institutes of Health http://dx.doi.org/10.13039/100000002 AI148302...
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Cell migration
J Cell Sci (2021) 134 (21): jcs258690.
Published: 4 November 2021
... detailed analysis of the complete leukocyte transendothelial migration process in real time. Leukocyte transendothelial migration Endothelial cells Inflammation Blood-vessel-on-a-chip Tissue Extracellular matrix Physiological hydrogel Blood vessels Migration dynamics Landsteiner...
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J Cell Sci (2020) 133 (24): jcs248864.
Published: 23 December 2020
... by IL-4 and mediates macrophage fusion for the formation of multinucleated giant cells. IL-4 Macrophage Monocyte Inflammation Mass spectrometry Foreign body giant cells Canadian Institutes of Health Research 10.13039/501100000024 MOP-142250 Alpha Omega Foundation...
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J Cell Sci (2020) 133 (23): jcs248344.
Published: 3 December 2020
... a CARD (ASC; also known as PYCARD), caspase-1 and probably other regulatory proteins, also bears considerable potential for detrimental inflammation, as observed in human conditions such as gout, heart attack, stroke and Alzheimer's disease. Thus, multi-layered regulatory networks are required to ensure...
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Organelles
J Cell Sci (2020) 133 (22): jcs247353.
Published: 30 November 2020
... chondrocytes through a mechanism that involves reactive oxygen species-dependent activation of the JNK/AP1 pathway. Osteoarthritis Chondrocytes Redox Inflammation JNK cFos AP1 National Institutes of Health 10.13039/100000002 R01-AT007373 National Institute of Arthritis...
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Cilia and flagella
J Cell Sci (2020) 133 (13): jcs239871.
Published: 8 July 2020
... of ciliary intraflagellar transport (IFT), altered the cell response to IL-1β, supporting a putative link emerging between cilia and inflammation. Here, we show that IFT88 depletion affects specific cytokine-regulated behaviours, changing cytosolic NFκB translocation dynamics but leaving MAPK signalling...
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J Cell Sci (2020) 133 (5): jcs239194.
Published: 30 December 2019
...Lin Luo; Richard M. Lucas; Liping Liu; Jennifer L. Stow; Ana-Maria Lennon-Duménil ABSTRACT Toll-like receptors (TLRs) are danger-sensing receptors that typically propagate self-limiting inflammatory responses, but can unleash uncontrolled inflammation in non-homeostatic or disease settings...
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J Cell Sci (2020) 133 (5): jcs236075.
Published: 26 September 2019
...David B. Gurevich; Kathryn E. French; John D. Collin; Stephen J. Cross; Paul Martin; Ana-Maria Lennon-Duménil ABSTRACT Implanting biomaterials in tissues leads to inflammation and a foreign body response (FBR), which can result in rejection. Here, we live image the FBR triggered by surgical suture...
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J Cell Sci (2019) 132 (17): jcs227728.
Published: 5 September 2019
..., junctional proteins and, consequently, endothelial barrier function. In this Review, we discuss the emerging role of ubiquitylation and deubiquitylation events in endothelial integrity and inflammation. The picture that emerges is one of increasing complexity, which is both fascinating and promising given...
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J Cell Sci (2019) 132 (7): jcs225615.
Published: 3 April 2019
... of TNF receptor superfamily members, such as the lymphotoxin-β receptor (LTβR), and is implicated in pathological angiogenesis associated with chronic inflammation and cancer. Here, we identify a previously unrecognized role of the LTβR–NIK axis during inflammatory activation of human endothelial cells...
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J Cell Sci (2019) 132 (1): jcs220228.
Published: 2 January 2019
...-specific receptor that stabilizes the vasculature in pathological angiogenesis. Although Robo4 has been shown to suppress vascular hyperpermeability induced by vascular endothelial growth factor (VEGF) in angiogenesis, the role of Robo4 in inflammation is poorly understood. In this study, we investigated...
Includes: Supplementary data