...Shannon McMahon; Steven Bergink; Harm H. Kampinga; Heath Ecroyd ABSTRACT Disturbances to protein homeostasis (proteostasis) can lead to protein aggregation and inclusion formation, processes associated with a variety of neurodegenerative disorders. DNAJB proteins are molecular chaperones that have...

...Rebecca San Gil; Dezerae Cox; Luke McAlary; Tracey Berg; Adam K. Walker; Justin J. Yerbury; Lezanne Ooi; Heath Ecroyd ABSTRACT Protein aggregates that result in inclusion formation are a pathological hallmark common to many neurodegenerative diseases, including amyotrophic lateral sclerosis...

... and in the centrosomal region, where it co-localizes withγ-tubulin. In Huntington's disease, inclusions are often nuclear or perinuclear. Since the perinuclear concentration of huntingtin does not depend on the number of its glutamine repeats, we propose that inclusions are found in perinuclear and intranuclear...