... at the immunological synapse. Furthermore, DISC1, Girdin and dynein are bound in a complex. Although this complex initially forms as a central patch at the synapse, it relocates to a peripheral ring corresponding to the peripheral supramolecular activation cluster (pSMAC). In the absence of DISC1, the classic actin...

... cell Immunological synapse National Institutes of Health 10.13039/100000002 HL0006060 RO1 DK084047 T cells are part of the adaptive immune system and use the T cell receptor (TCR) to recognize foreign peptides on the surface of antigen-presenting cells (APCs). Engagement...

...Chloé Guedj; Nicolas Abraham; Damien Jullié; Clotilde Randriamampita ABSTRACT The immunological synapse forms at the interface between a T cell and an antigen-presenting cell after foreign antigen recognition. The immunological synapse is considered to be the site where the signaling cascade...

..., with a key component of inside-out signaling, namely the active form of the small GTPase Rap1 (which has two isoforms, Rap1A and Rap1B). This interaction has been further shown to facilitate the interdependent recruitment of Rap1 and SLAT to the T cell immunological synapse upon TCR engagement. Furthermore...

... is the recruitment of SNX27 to endosomes which is mediated by the binding of phosphatidylinositol-3-phosphate (PtdIns3 P ) by its phox homology (PX) domain. In T-cells, SNX27 localizes to the immunological synapse in an activation-dependent manner, but the molecular mechanisms underlying SNX27 translocation remain...

...Joost te Riet; Jonne Helenius; Nico Strohmeyer; Alessandra Cambi; Carl G. Figdor; Daniel J. Müller ABSTRACT At the immunological synapse, the activated leukocyte cell adhesion molecule (ALCAM) on a dendritic cell (DC) and CD6 molecules on a T cell contribute to sustained DC–T-cell contacts. However...

... synapse. * Authors for correspondence ( [email protected] ; [email protected] ) © 2013. Published by The Company of Biologists Ltd 2013 T cell activation T cell receptor Actin Antigen-presenting cell Microcluster Immunological synapse Membrane spatial organization T cells have...

... proteins to microclusters at the cell-cell interface known as the immunological synapse (IS). The Vav1 guanine nucleotide exchange factor plays a critical role in T cell antigen receptor (TCR) signalling, leading to the activation of multiple pathways. We now show that it is recruited to microclusters...

.... , Rieger H. , Quintana A. , Hoth M. ( 2009 ). The immunological synapse controls local and global calcium signals in T lymphocytes . Immunol. Rev. 231 , 132 - 147 . Laemmli U. ( 1970 ). Cleavage of structural proteins during the assembly of the head of bacteriophage T4...

... endosomes polarise to the immunological synapse. A fraction of SNX27 accumulates at the mature immunological synapse in a process that is dependent on vesicular trafficking, binding of the PX domain to phosphatidylinositol 3-phosphate and the presence of the PDZ region. Downmodulation of expression...

... for the recruitment of proteins that promote actin polymerization at the interface of T cells and APCs. * Author for correspondence ( [email protected] ) 4 11 2010 © 2011. 2011 Actin Clathrin Cytoskeleton Immunological synapse T cells have a central role in adaptive immunity...

...-mail: [email protected] 6 11 2007 © The Company of Biologists Limited 2008 2008 T cells Polarity Immunological synapse Until recently, shape was rarely considered of importance to the biology of lymphocytes, which, with a few exceptions, were generally depicted as spheres...