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Keywords: Immunological synapse
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Journal Articles
J Cell Sci (2020) 133 (13): jcs242875.
Published: 6 July 2020
... at the immunological synapse. Furthermore, DISC1, Girdin and dynein are bound in a complex. Although this complex initially forms as a central patch at the synapse, it relocates to a peripheral ring corresponding to the peripheral supramolecular activation cluster (pSMAC). In the absence of DISC1, the classic actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (13): jcs242875.
Published: 6 July 2020
... at the immunological synapse. Furthermore, DISC1, Girdin and dynein are bound in a complex. Although this complex initially forms as a central patch at the synapse, it relocates to a peripheral ring corresponding to the peripheral supramolecular activation cluster (pSMAC). In the absence of DISC1, the classic actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2405–2415.
Published: 15 July 2017
... cell Immunological synapse T cells are part of the adaptive immune system and use the T cell receptor (TCR) to recognize foreign peptides on the surface of antigen-presenting cells (APCs). Engagement of the TCR initiates T cell signaling, polarization and activation. This phenomena may last...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2405–2415.
Published: 15 July 2017
... cell Immunological synapse National Institutes of Health 10.13039/100000002 HL0006060 RO1 DK084047 T cells are part of the adaptive immune system and use the T cell receptor (TCR) to recognize foreign peptides on the surface of antigen-presenting cells (APCs). Engagement...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (13): 2526–2537.
Published: 1 July 2016
...Chloé Guedj; Nicolas Abraham; Damien Jullié; Clotilde Randriamampita ABSTRACT The immunological synapse forms at the interface between a T cell and an antigen-presenting cell after foreign antigen recognition. The immunological synapse is considered to be the site where the signaling cascade...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (13): 2526–2537.
Published: 1 July 2016
...Chloé Guedj; Nicolas Abraham; Damien Jullié; Clotilde Randriamampita ABSTRACT The immunological synapse forms at the interface between a T cell and an antigen-presenting cell after foreign antigen recognition. The immunological synapse is considered to be the site where the signaling cascade...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (23): 4341–4352.
Published: 1 December 2015
..., with a key component of inside-out signaling, namely the active form of the small GTPase Rap1 (which has two isoforms, Rap1A and Rap1B). This interaction has been further shown to facilitate the interdependent recruitment of Rap1 and SLAT to the T cell immunological synapse upon TCR engagement. Furthermore...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (3): 553–565.
Published: 1 February 2015
... is the recruitment of SNX27 to endosomes which is mediated by the binding of phosphatidylinositol-3-phosphate (PtdIns3 P ) by its phox homology (PX) domain. In T-cells, SNX27 localizes to the immunological synapse in an activation-dependent manner, but the molecular mechanisms underlying SNX27 translocation remain...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1595–1606.
Published: 1 April 2014
...Joost te Riet; Jonne Helenius; Nico Strohmeyer; Alessandra Cambi; Carl G. Figdor; Daniel J. Müller ABSTRACT At the immunological synapse, the activated leukocyte cell adhesion molecule (ALCAM) on a dendritic cell (DC) and CD6 molecules on a T cell contribute to sustained DC–T-cell contacts. However...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1049–1058.
Published: 1 March 2013
... synapse. Fig. 4. The frictional coupling model for the translocation and spatial segregation of microclusters. ( A ) Schematic illustration of the frictional coupling model, in which microclusters of membrane receptors are translocated towards the center of an immunological synapse between a T cell...
Journal Articles
J Cell Sci (2012) 125 (22): 5302–5314.
Published: 15 November 2012
... proteins to microclusters at the cell-cell interface known as the immunological synapse (IS). The Vav1 guanine nucleotide exchange factor plays a critical role in T cell antigen receptor (TCR) signalling, leading to the activation of multiple pathways. We now show that it is recruited to microclusters...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (19): 3266–3278.
Published: 1 October 2011
... Biochemie, 35392 Giessen, Germany ‡ Author for correspondence ( renkawit@biologie.uni-marburg.de ) 30 5 2011 © 2011. 2011 Drosophila Swip-1 CG10641 Calcium Myogenesis Immunological synapse FuRMAS Singles bar Sticks-and-stones SL2 cells Actin foci Membrane fusion...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2011) 124 (5): 776–788.
Published: 1 March 2011
... endosomes polarise to the immunological synapse. A fraction of SNX27 accumulates at the mature immunological synapse in a process that is dependent on vesicular trafficking, binding of the PX domain to phosphatidylinositol 3-phosphate and the presence of the PDZ region. Downmodulation of expression...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (2): 131–136.
Published: 15 January 2008
..., A., Harriague, J., Bismuth, G., Utzny, C., Muller, S. and Valitutti, S. ( 2005 ). Immunological synapses are versatile structures enabling selective T cell polarization. Immunity 22 , 185 -194. Dustin, M. L. and Chan, A. C. ( 2000 ). Signaling takes shape in the immune system. Cell 103 , 283 -294...