...Roy Cohen; Kathryn Corwith; David Holowka; Barbara Baird Summary Mast cell activation initiated by antigen-mediated crosslinking of IgE receptors results in stimulated exocytosis of secretory lysosomes in the process known as degranulation. Much has been learned about the molecular mechanisms...

...Lavanya Vasudevan; Andreas Jeromin; Laura Volpicelli-Daley; Pietro De Camilli; David Holowka; Barbara Baird Crosslinking of IgE receptors by antigen initiates Ca 2+ mobilization in mast cells by activating phospholipase-Cγ-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5) P...

... (RBL) mast cells to a surface that was patterned on the μm scale with hapten-containing lipid bilayers to activate cell surface IgE-receptor complexes. We find that, within 10 minutes of stimulation, fusion of individual secretory lysosomes is targeted towards the cell-substrate interface...

... Research Building,Nashville, TN 37232-6600, USA 15 4 2003 © The Company of Biologists Limited 2003 2003 Ceramides Lipid rafts IgE receptors Phospholipase D Mast cells Considerable evidence has accumulated for an important role of the plasma membrane structure in signal...