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Keywords: IQGAP1
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Journal Articles
J Cell Sci (2015) 128 (5): 853–862.
Published: 01 March 2015
...Barbara E. Tanos; Andres E. Perez Bay; Susana Salvarezza; Igor Vivanco; Ingo Mellinghoff; Mahasin Osman; David B. Sacks; Enrique Rodriguez-Boulan ABSTRACT IQGAP1 is a scaffolding protein previously implicated in adherens junction formation. However, its role in the establishment or maintenance...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (18): 4121–4135.
Published: 15 September 2013
... defined, the mechanisms that are responsible for switching off activity are poorly understood. Here, proteomic analysis of activated integrin-associated complexes suggests filamin-A and IQ-motif-containing GTPase-activating protein 1 (IQGAP1) as candidates that link β1 integrin to Rac1. siRNA-mediated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (8): 2041–2052.
Published: 15 April 2012
...Yemsrach K. Tekletsadik; Robert Sonn; Mahasin A. Osman Defining the mechanisms that control cell growth and division is crucial to understanding cell homeostasis, which impacts human diseases such as cancer and diabetes. IQGAP1, a widely conserved effector and/or regulator of the GTPase CDC42...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (20): 3515–3524.
Published: 15 October 2011
...) and ERK1/2 and that melusin-bound mitogen-activated protein kinases (MAPKs) are activated by pressure overload. Moreover, we demonstrate that both focal adhesion kinase (FAK) and IQ motif-containing GTPase activating protein 1 (IQGAP1), a scaffold protein for the ERK1/2 signalling cascade, are part...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (15): 2529–2538.
Published: 01 August 2011
.... Silencing of 4.1R caused the loss of persistence of migration in subconfluent cells and of directional migration in cells moving into a wound. Coimmunoprecipitation and pull-down assays identified the scaffold protein IQGAP1 as a partner for protein 4.1R and showed that the 4.1R membrane-binding domain...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (16): 2969–2979.
Published: 15 August 2009
... for this asymmetric distribution of CLASPs. However, it is not known how GSK-3β regulates the activity of CLASPs for linkage between actin and microtubules. Here we identified IQGAP1, an actin-binding protein, as a novel CLASP-binding protein. GSK-3β directly phosphorylates CLASP2 at Ser533 and Ser537 within...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (12): 2024–2033.
Published: 15 June 2009
...Jian-Bin Wang; Robert Sonn; Yemmsrach K. Tekletsadik; Daniel Samorodnitsky; Mahasin A. Osman Cell proliferation requires close coordination of cell growth and division to ensure constant cell size through the division cycles. IQGAP1, an effector of CDC42 GTPase has been implicated in the modulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (3): 391–403.
Published: 01 February 2008
... Iqg1p has been identified as a positional marker linking polarity and exocytosis cues, studies on its mammalian counterpart, IQGAP1, have focused on its role in organizing cytoskeletal architecture, for which the underlying mechanism is unclear. Here, we report that IQGAP1 associates and co-localizes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (19): 3327–3335.
Published: 01 October 2007
... domains, through which it binds to various proteins, including β-catenin, axin, CtBP, Asefs, IQGAP1, EB1 and microtubules. Studies using mutant mice and cultured cells have demonstrated that APC suppresses canonical Wnt signalling, which is essential for tumorigenesis, development and homeostasis...
Journal Articles
J Cell Sci (2005) 118 (10): 2085–2092.
Published: 15 May 2005
... during tissue development, chemotaxis and wound healing. Rho-family small GTPases, especially Rac1 and Cdc42, play pivotal roles in these processes through one of their effectors, IQGAP1. Recent studies reveal that IQGAP1 regulates cadherin-mediated cell-cell adhesion both positively and negatively...