... of interleukin-1β (IL-1β). These findings identify a novel mechanism of host autophagy modulation and immune modulation employed by V. cholerae during bacterial infection. * These authors contributed equally to this work ‡ Authors for correspondence ( [email protected] ; [email protected]...

...Maria Teresa Pallotta; Walter Nickel ABSTRACT Fibroblast growth factor 2 (FGF2) and interleukin 1β (IL-1β) were among the earliest examples of a subclass of proteins with extracellular functions that were found to lack N-terminal secretory signal peptides and were shown to be secreted in an ER...

... particle to the macrophage plasma membrane by a ‘bystander’ mechanism. This MAC-mediated bystander damage initiates NLRP3 inflammasome activation, resulting in caspase-1 activation and IL-1β and IL-18 secretion. Inflammasome activation is not induced when macrophages phagocytize unopsonized particles...

...Richard S. Beard, Jr; Ricci J. Haines; Kevin Y. Wu; Jason J. Reynolds; Stephanie M. Davis; John E. Elliott; Nikolay L. Malinin; Victor Chatterjee; Byeong J. Cha; Mack H. Wu; Sarah Y. Yuan ABSTRACT Aberrant elevation in the levels of the pro-inflammatory cytokine interleukin-1β (IL-1β) contributes...

...) and ryanodine receptor (RyR) channels. This increase in intracellular Ca 2+ concentration leads to Ca 2+ accumulation in the mitochondrial matrix via the ‘mitochondrial calcium uniporter’ (MCU), and loss of mitochondrial transmembrane potential, triggering NLRP3 inflammasome activation and IL-1β release. NLRP3...

...) in SCs and the injured sciatic nerve in vivo. TXNIP is involved in the activation of p38 MAPK, CREB and NFκB in SCs. TXNIP silencing partially inhibits RAGE-induced SC migration and completely abolishes RAGE-induced fibronectin and IL-1β expression. Our results support a model in which TXNIP mediates...

.... The time course for expression pattern and level for cartilage specific markers, type II collagen and aggrecan, and regulators of chondrogenesis, Sox9 and IL-1β, were analyzed and compared with non-compressed control cultures. Under compressive conditions, histological evaluation showed an apparent...