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Keywords: IKK
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Journal Articles
J Cell Sci (2010) 123 (24): 4231–4239.
Published: 15 December 2010
... is downregulation of the adherens junction protein E-cadherin, a process mediated by transcription factors such as the zinc fingers SNAIL and SLUG. Here, we report that the catalytic IκB kinase (IKK) subunit IKKα is necessary for the silencing of E-cadherin in a Panc1 cell model of TGFβ–SMAD-mediated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2005) 118 (24): 5785–5796.
Published: 15 December 2005
... of host IKK function. In the present study, we examined the roles of host IKK and parasite-derived TgIKK on the temporal modulation of NF-κB activation. Despite the presence of TgIKK activity at the PVM, nuclear translocation of NF-κB and subsequent gene expression exhibited a requirement for the...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (18): 3721–3728.
Published: 15 September 2003
... activation pathway by interaction with IκB kinase (IKK). In a yeast-two-hybrid screen, we identified IKKγ as an interacting partner of vFLIP. We expressed fragments of IKKγ in mammalian cells and bacteria, and identified the central CCR3/4 (amino acids 150-272) as the vFLIP binding region. To investigate the...
Journal Articles
J Cell Sci (2002) 115 (1): 141–151.
Published: 01 January 2002
... proteins. During response to diverse stimuli, IκBs are rapidly phosphorylated by IκB kinases (IKKs), ubiquitinated and undergo degradation. We have investigated the expression and function of NF-κB, IκB inhibitors and IKKs in normal prostate epithelial cells and prostate carcinoma (PC) cell lines LNCaP...