...Thea Shavlakadze; Jinfen Chai; Kirsten Maley; Greg Cozens; Griffin Grounds; Nadine Winn; Nadia Rosenthal; Miranda D. Grounds Here, we characterise new strains of normal and dystrophic ( mdx ) mice that overexpress Class 2 IGF-1 Ea in skeletal myofibres. We show that transgenic mice have increased...

... at the nerve growth cone. We have demonstrated recently that plasmalemmal expansion is regulated at the growth cone by IGF-1, but not by BDNF, in a manner that is quasi independent of the neuron's perikaryon. To begin elucidating the signaling pathway by which exocytosis of the plasmalemmal precursor...

... growth factor 1 (IGF-1) influence keratinocyte shape differently. Whereas IGF-1 stimulates membrane protrusion and facilitates cell spreading, EGF induces contraction of keratinocytes. The effects of each growth factor on keratinocyte shape are mediated by distinct signal transduction pathways: EGF...

... and cultures stimulated with brain-derived neurotrophic factor (BDNF), PPV clusters persisted in growth cones with a half-life( t 1/2 ) of >14 minutes. Upon challenge with IGF-1,however, fluorescent elements cleared from the growth cones with a t 1/2 of only 6 minutes. Plasmalemmal expansion was measured...