...Shangjin Shao; Yuling Chen; Haiteng Deng; Junmin Pan ABSTRACT Intraflagellar transport (IFT) is required for ciliary assembly. The IFT machinery comprises the IFT motors kinesin-2 and IFT dynein plus IFT-A and IFT-B complexes, which assemble into IFT trains in cilia. To gain mechanistic...

...Mareike A. Jordan; Gaia Pigino ABSTRACT The intraflagellar transport (IFT) system is a remarkable molecular machine used by cells to assemble and maintain the cilium, a long organelle extending from eukaryotic cells that gives rise to motility, sensing and signaling. IFT plays a critical role...

...Joost R. Broekhuis; Suzanne Rademakers; Jan Burghoorn; Gert Jansen Summary Primary cilia are microtubule-based organelles that have important sensory functions. For their function, cilia rely on the delivery of specific proteins, both by intracellular trafficking and intraflagellar transport (IFT...

...Jan Burghoorn; Martijn P. J. Dekkers; Suzanne Rademakers; Ton de Jong; Rob Willemsen; Peter Swoboda; Gert Jansen Cilia length and function are dynamically regulated by modulation of intraflagellar transport (IFT). The cilia of C. elegans amphid channel neurons provide an excellent model to study...

...Christopher Boehlke; Mikhail Bashkurov; Andrea Buescher; Theda Krick; Anne-Katharina John; Roland Nitschke; Gerd Walz; E. Wolfgang Kuehn The structure and function of the primary cilium as a sensory organelle depends on a motor-protein-powered intraflagellar transport system (IFT); defective IFT...

..., we characterized the novel cilia protein T28F3.6 (IFTA-2, intraflagellar transport associated protein 2), which is homologous to the mammalian Rab-like 5 protein. We found that, unlike the intraflagellar transport (IFT) genes, disruption of ifta-2 does not result in overt cilia assembly abnormalities...