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Keywords: Hypoxia
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Journal Articles
In collection:
Metabolism
J Cell Sci (2021) 134 (20): jcs258469.
Published: 20 October 2021
...Gregory G. Fuller; John K. Kim ABSTRACT Hypoxia inhibits the tricarboxylic acid (TCA) cycle and leaves glycolysis as the primary metabolic pathway responsible for converting glucose into usable energy. However, the mechanisms that compensate for this loss in energy production due to TCA cycle...
Journal Articles
J Cell Sci (2021) 134 (12): jcs258575.
Published: 17 June 2021
...Madelyn K. Logan; Katheryn E. Lett; Michael D. Hebert ABSTRACT Hypoxia is a severe stressor to cellular homeostasis. At the cellular level, low oxygen triggers the transcription of a variety of genes supporting cell survival and oxygen homeostasis mediated by transcription factors, such as hypoxia...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs256255.
Published: 22 February 2021
... quantitative intravital imaging to illuminate mitophagy during physiological stresses, namely, embryonic development, fasting and hypoxia. In fasted muscle, volumetric mitolysosome size analyses documented organelle stress response dynamics, and time-lapse imaging revealed that mitochondrial filaments undergo...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (1): jcs250274.
Published: 11 January 2021
... development and embryonic lethality. Although hypoxia is implicated in vascular remodelling and angiogenesis, its effect on PTP-PEST remains unexplored. Here we report that hypoxia (1% oxygen) increases protein levels and catalytic activity of PTP-PEST in primary endothelial cells. Immunoprecipitation...
Includes: Supplementary data
Journal Articles
In collection:
Metabolism
J Cell Sci (2020) 133 (10): jcs241463.
Published: 29 May 2020
... extracellular and intracellular adenosine provides a sufficient justification for reexamination of the current concepts of cellular purine homeostasis and signaling in cancer. This article has an associated First Person interview with the first author of the paper . Cancer cells Hypoxia Adenosine...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (5): jcs223230.
Published: 18 February 2019
... program, whereas microenvironmental conditions such as reduced tissue oxygenation have an inhibitory effect. We investigated the effects of hypoxia on myofibroblastic properties and linked this to RhoA activity. Hypoxia reversed the myofibroblastic phenotype of primary fibroblasts. This was accompanied...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (22): jcs219782.
Published: 19 November 2018
...Yihua Wang; Shan Zhong; Christopher J. Schofield; Peter J. Ratcliffe; Xin Lu ABSTRACT Hypoxia plays a crucial role at cellular and physiological levels in all animals. The responses to chronic hypoxia are, at least substantially, orchestrated by activation of the hypoxia inducible transcription...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2018) 131 (10): jcs210906.
Published: 23 May 2018
...Irina Raykhel; Fazeh Moafi; Satu M. Myllymäki; Patricia G. Greciano; Karl S. Matlin; Jose V. Moyano; Aki Manninen; Johanna Myllyharju ABSTRACT Hypoxia and loss of cell polarity are common features of malignant carcinomas. Hypoxia-inducible factor 1 (HIF1) is the major regulator of cellular hypoxia...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2292–2305.
Published: 15 July 2017
...Iman Azimi; Michael J. G. Milevskiy; Elke Kaemmerer; Dane Turner; Kunsala T. D. S. Yapa; Melissa A. Brown; Erik W. Thompson; Sarah J. Roberts-Thomson; Gregory R. Monteith ABSTRACT Hypoxia is a feature of the tumour microenvironment that promotes invasiveness, resistance to chemotherapeutics...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 466–479.
Published: 15 January 2017
...Ilias Mylonis; Maria Kourti; Martina Samiotaki; George Panayotou; George Simos Hypoxia inducible factor-1 (HIF-1) is the main transcriptional activator of the cellular response to hypoxia and an important target of anticancer therapy. Phosphorylation by ERK1 and/or ERK2 (MAPK3 and MAPK1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (15): 2887–2896.
Published: 1 August 2016
... metabolism, proliferation, cell survival and fate. Organisms or tissues rapidly respond to changes in oxygen availability by activating complex signalling networks, which culminate in the control of mRNA translation and/or gene expression. This Commentary presents the effects of hypoxia during embryonic...
Journal Articles
J Cell Sci (2016) 129 (1): 191–205.
Published: 1 January 2016
...Brian Ortmann; Dalila Bensaddek; Sara Carvalhal; Sandra C. Moser; Sharon Mudie; Eric R. Griffis; Jason R. Swedlow; Angus I. Lamond; Sonia Rocha ABSTRACT PHD1 (also known as EGLN2) belongs to a family of prolyl hydroxylases (PHDs) that are involved in the control of the cellular response to hypoxia...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (17): 3317–3329.
Published: 1 September 2015
...Shanshan Li; Jinkui Wang; Yi Wei; Yongjian Liu; Xia Ding; Bin Dong; Yinghui Xu; Yizheng Wang ABSTRACT Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor responsible for the expression of a broad range of genes that facilitate acclimatization to hypoxia. Its stability is predominantly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (16): 3082–3093.
Published: 15 August 2015
...Sonia Moniz; Daniel Bandarra; John Biddlestone; Kirsteen J. Campbell; David Komander; Anja Bremm; Sonia Rocha ABSTRACT Mechanisms regulating protein degradation ensure the correct and timely expression of transcription factors such as hypoxia inducible factor (HIF). Under normal O 2 tension, HIFα...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (8): 1475–1480.
Published: 15 April 2015
... and HSP90AB1, respectively) work together to promote cell motility in wounded skin and accelerate wound closure. We demonstrate that Hsp90α and Hsp90β have distinct and non‐exchangeable functions during wound healing. Under hypoxia and when there is a lack of serum factors, Hsp90β binds to the cytoplasmic tail...
Journal Articles
J Cell Sci (2015) 128 (6): 1083–1089.
Published: 15 March 2015
.... TGF-β and hypoxia, two cues that initiate injury-induced fibrosis, caused human kidney cells to develop a mesenchymal phenotype, including increased fibronectin expression and secretion. However, upon hypoxia, assembled extracellular fibronectin fibrils were mostly absent, whereas treatment with TGF-β...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (2): 225–231.
Published: 15 January 2015
... known as HIF1AN) is an oxygen-dependent asparaginyl hydroxylase that regulates the hypoxia-inducible factors (HIFs). Several proteins containing ankyrin repeat domains (ARDs) have been characterised as substrates of FIH, although there is little evidence for a functional consequence of hydroxylation...
Journal Articles
J Cell Sci (2015) 128 (1): 40–49.
Published: 1 January 2015
... activity or HIF1α stability, providing new evidence for a dual role of PHD3 in HIF1 regulation. Moreover, we show that hypoxia modulates PHD3–SUMO conjugation and that this modification inversely correlates with HIF1 activation. PHD3 SUMOylation highlights a new and additional layer of regulation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (7): 1585–1594.
Published: 1 April 2014
...Kenji Takahashi; Irene K. Yan; Hiroaki Haga; Tushar Patel ABSTRACT Resistance to adverse environmental conditions, such as hypoxia, contributes to the reduced efficacy of anticancer therapies and tumor progression. Although deregulated expression of many long noncoding RNA (lncRNA) occurs in human...
Journal Articles
J Cell Sci (2014) 127 (2): 455–464.
Published: 15 January 2014
... on gap junctions with Akt inhibitors, we created an antibody specific for Cx43 phosphorylated on S373, a potential Akt substrate. We found S373 phosphorylation in cells and skin or heart almost exclusively in larger gap-junctional structures that increased dramatically after wounding or hypoxia. We were...