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Keywords: Hypothalamus
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Journal Articles
Kazuhito Sai, Sho Morioka, Giichi Takaesu, Nagendran Muthusamy, H. Troy Ghashghaei, Hiroshi Hanafusa, Kunihiro Matsumoto, Jun Ninomiya-Tsuji
Journal:
Journal of Cell Science
J Cell Sci (2016) 129 (9): 1855–1865.
Published: 1 May 2016
... upregulated SREBP-target lipogenic genes and blocked ER stress in the hypothalamus. Furthermore, CNS-specific Tak1 deletion prevented ER-stress-induced hypothalamic leptin resistance and hyperphagic obesity under a high-fat diet (HFD). Thus, TAK1 is a crucial regulator of ER stress in vivo , which could...
Includes: Supplementary data
