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Keywords: Hypomethylation
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Journal Articles

5-Aza-2′-deoxycytidine advances the epithelial–mesenchymal transition of breast cancer cells by demethylating Sipa1 promoter-proximal elements

Open Access
In collection:
Cell biology and disease
Ang Lu, Wei Wang, Shu-Fang Wang-Renault, Brian Z. Ring, Yoshimasa Tanaka, Jun Weng, Li Su
Journal: Journal of Cell Science
J Cell Sci (2020) 133 (9): jcs236125.
https://doi.org/10.1242/jcs.236125
Published: 11 May 2020
... knocking down Sipa1 in MDA-MB-231 cells. However, the EMT was promoted in MCF7 cells with over-expression of SIPA1 or treated with 5-Aza-CdR. Taken together, hypomethylation of the CpG island in Sipa1 promoter-proximal elements could enhance SIPA1 expression in breast cancer cells, which could facilitate...
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Includes: Supplementary data