...Marion Thauvin; Rodolphe Matias de Sousa; Marine Alves; Michel Volovitch; Sophie Vriz; Christine Rampon ABSTRACT Reactive oxygen species (ROS), originally classified as toxic molecules, have attracted increasing interest given their actions in cell signaling. Hydrogen peroxide (H 2 O 2), the major...

... kinase α and de-repression of epidermal growth factor promoter activity stimulates keratinocyte migration. Wound repair Wound healing Keratinocytes Migration Reactive oxygen species Hydrogen peroxide H 2 O 2 IKKα Sulfenylation EGF Nuclear de-repression HEK001 Oxidation...

... pathways. *Author for correspondence (e-mail: [email protected]) 13 8 2001 © The Company of Biologists Limited 2001 2001 Adaptation SAPK/JNK Hydrogen peroxide Oxidative stress Cell death Although oxidative stress is generally considered to be cytotoxic, it can...

... Melanogenesis Oxidative stress Hydrogen peroxide Hypopigmentation Microphthalmia Mammalian pigmentation results from the synthesis and accumulation of photoprotective epidermal melanins. Melanins are formed from the amino acid precursor L-tyrosine within specialized cells: the melanocytes...

... recently recognized as a basal source of hydrogen peroxide in the extracellular space. Significant levels of GGT activity are expressed by malignant tumours, and in melanoma cell lines they were found to correlate with the malignant behaviour. As hydrogen peroxide and other oxidants can affect signal...

...Lan Jornot; Pierre Maechler; Claes B. Wollheim; Alain F. Junod ABSTRACT In endothelial cells, a bolus of hydrogen peroxide (H 2 O 2) or oxygen metabolites generated by hypoxanthine-xanthine oxidase (HX-XO) increased the mitochondrial calcium concentration [Ca 2+ ] m . Both agents caused a biphasic...