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Keywords: Human
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Journal Articles
J Cell Sci (2018) 131 (22): jcs221994.
Published: 19 November 2018
... the molecular mechanisms that regulate basal lipolysis. Here, we describe a mechanism whereby autocrine purinergic signalling and constitutive P2Y 2 receptor activation suppresses basal lipolysis in primary human in vitro -differentiated adipocytes. We found that human adipocytes possess cytoplasmic Ca 2+ tone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (18): 3083–3093.
Published: 15 September 2017
...Julie Perroud; Laurent Bernheim; Maud Frieden; Stephane Koenig ABSTRACT Ca 2+ signaling plays a key role during human myoblast differentiation. Among Ca 2+ -sensitive pathways, calcineurin is essential for myoblast differentiation and muscle regeneration. Nuclear factor of activated T-cell (NFAT...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (17): 4114–4125.
Published: 1 September 2012
...Manabu Ohyama; Tetsuro Kobayashi; Takashi Sasaki; Atsushi Shimizu; Masayuki Amagai Summary The dermal papilla (DP) plays pivotal roles in hair follicle morphogenesis and cycling. However, characterization and/or propagation of human DPs have been unsatisfactory because of the lack of efficient...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (23): 4063–4075.
Published: 1 December 2010
..., chromosomes are organized in territories that are radially positioned in the nucleus. However, it remains unclear whether chromosomes are organized relative to each other. Here, we examine the nuclear arrangement of 10 chromosomes in human epithelial cancer cells by three-dimensional FISH analysis. We show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (13): 2130–2135.
Published: 1 July 2008
... Exocytosis Human Sperm Over 80 million people worldwide experience infertility and over one third of infertility cases are due to male factors, i.e. sperm dysfunction ( http://www.who.int/reproductive-health/infertility/report.pdf ), but 20-30% of these are classified `normal' by standard semen...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (12): 2613–2620.
Published: 15 June 2006
...C. Christodoulides; M. Laudes; W. P. Cawthorn; S. Schinner; M. Soos; S. O'Rahilly; J. K. Sethi; A. Vidal-Puig Secretion of Wnts by adipose cells has an important role in the control of murine adipogenesis. We present the first evidence that a Wnt antagonist, Dickkopf 1 (Dkk1), is secreted by human...
Journal Articles
J Cell Sci (2006) 119 (3): 416–424.
Published: 1 February 2006
..., human gamete fusion remains largely unknown. We now show that an anti-α6 integrin mAb (GoH3) strongly inhibited human sperm-egg fusion in human zona-free eggs. Furthermore, a mAb directed against CD151, a tetraspanin known to associate with α6β1, partially inhibited sperm-egg fusion. By contrast...
Journal Articles
J Cell Sci (2005) 118 (15): 3247–3261.
Published: 1 August 2005
... ( Novac et al., 2001 ), as well as in Chinese hamster ovary (CHO) cells ( Matheos et al., 2003 ). In this study, ChIP analyses revealed the specific association of Ku with the lamin B2, β-globin and c- myc origins of DNA replication in vivo in human cells (Figs 8 and 9 ). Orc2 protein, a subunit...
Includes: Supplementary data
Journal Articles
J Cell Sci (2003) 116 (13): 2763–2774.
Published: 1 July 2003
... are human homologues of the only known protein mediators of mitochondrial fusion, the Drosophila Fzo GTPase and Saccharomyces cerevisiae yFzo1p. Although the Mfn1 and Mfn2 genes were broadly expressed, the two genes showed different levels of mRNA expression in different tissues. Two Mfn1 transcripts were...
Journal Articles
J Cell Sci (2002) 115 (15): 3131–3138.
Published: 1 August 2002
...Daniela Uberti; Teresina Carsana; Enza Bernardi; Luigi Rodella; Piergiovanni Grigolato; Cristina Lanni; Marco Racchi; Stefano Govoni; Maurizio Memo In this study, we evaluated the response of different human skin fibroblast cultures obtained from eight probable Alzheimer's disease patients...
Journal Articles
J Cell Sci (2002) 115 (13): 2679–2688.
Published: 1 July 2002
...Harmeet Malhi; Adil N. Irani; Singh Gagandeep; Sanjeev Gupta The liver can regenerate itself through the progenitor cells it harbors. Here we demonstrate isolation of epithelial progenitor/stem cells from the fetal human liver, which contains a large number of hepatoblasts. Progenitor liver cells...
Journal Articles
J Cell Sci (2001) 114 (15): 2735–2746.
Published: 1 August 2001
...-FLIP-sense: 5′-ATTGGTGAGGATTTGGATAAATCTG-3′, c-FLIP-antisense: 5′-GTGGGCGTTTTCTTTCTTGTCTC-3′. CD95-induced cell death Pancreatic cancer Human Immune escape Extracellular signals that are transduced into the cell via the CD95 (Fas, APO-1) receptor regulate cell death and survival...