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Keywords: Hsp90
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Journal Articles
J Cell Sci (2020) 133 (13): jcs244863.
Published: 07 July 2020
... that the silencing of reporter genes at major native heterochromatic loci (centromeres, telomeres, mating-type locus and rDNA regions) and an artificially induced heterochromatin locus is alleviated in a fission yeast hsp90 mutant, hsp90-G84C . Also, H3K9me2 enrichment at heterochromatin regions, especially...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs238873.
Published: 16 June 2020
... the drug did not inhibit GR nuclear export itself. This indicates the existence of a TPR-domain-dependent mechanism for the export of nuclear proteins. The expression balance of those TPR domain proteins bound to the GR–Hsp90 complex may determine the subcellular localization and nucleocytoplasmic...
Includes: Supplementary data
Journal Articles
In collection:
J Cell Sci (2020) 133 (2): jcs236786.
Published: 23 January 2020
...)-containing protein that has been proposed to function as an Hsp90 co-chaperone. Morgana deregulation promotes carcinogenesis in both mice and humans while, in Drosophila , loss of mora causes lethality and a complex mitotic phenotype that is rescued by a human morgana transgene. Here, we show that Drosophila...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (21): 4143–4154.
Published: 01 November 2016
... localization of the glucocorticoid receptor that is dependent on the time of day is altered at the post-translational level by the absence of REV-ERBα, affecting expression GR target genes. Nuclear receptor Circadian clock Glucocorticoid receptor REV-ERBα HSP90 In mammals, the circadian clock...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (21): 5196–5207.
Published: 01 November 2012
... with the heat shock proteins HSP90 and HSP70 via a cytosol-exposed TPR domain. We further show by in vitro and in vivo experiments that AtTPR7 is associated with the Arabidopsis Sec63 homologue, AtERdj2. Interestingly, AtTPR7 can functionally complement a Δ sec71 yeast mutant that is impaired in post...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (18): 3164–3173.
Published: 15 September 2011
... that the myosin-binding UCS domain of UNC-45 alone is sufficient to rescue lethal unc-45 null mutants arrested in embryonic muscle development and temperature-sensitive loss-of-function unc-45 mutants defective in worm A-band assembly. Removal of the Hsp90-binding TPR domain of UNC-45 does not affect rescue...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (5): 717–723.
Published: 01 March 2008
...Gregor P. Lotz; Alexander Brychzy; Stefan Heinz; Wolfgang M. J. Obermann Heat shock protein 90 (HSP90) is considered a specialized molecular chaperone that controls the folding of cell-regulatory proteins such as steroid receptors and kinases. However, its high abundance is suggestive of a more...
Journal Articles
J Cell Sci (2007) 120 (10): 1743–1751.
Published: 15 May 2007
... was finally resuspended in 40 μl LSC. Membrane-insertion reactions comprised 2 μl of isolated RNCs made up to a final volume of 10 μl by LSC and various additions. Hsp40 was added at 3 μM, Hsc70 was added at 1.7 μM, Hsp90 was added at 1.3 μM, TRiC (gift from Judith Frydman, James Clark Center, Stanford...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (7): 1278–1287.
Published: 01 April 2007
... localisation are poorly understood. To understand how cyclin B is targeted to different locations in the cell we have isolated proteins that interact with cyclin B in Drosophila embryo extracts. Here we show that cyclin B interacts with the molecular chaperone Hsp90 and with the MT-associated protein (MAP...
Journal Articles
J Cell Sci (2004) 117 (24): 5759–5770.
Published: 15 November 2004
...-TRAP1 is translocated to mitochondria by sensing the cell density in growth medium and enhances the early developmental program through a novel prestarvation response. In the Hsp90 family, TRAP-1 has a mitochondrial localization sequence at its N-terminus ( Song et al., 1995 ; Felts et al., 2000...
Journal Articles
J Cell Sci (2004) 117 (5): 701–710.
Published: 15 February 2004
...Victoria M. Longshaw; J. Paul Chapple; Maria S. Balda; Michael E. Cheetham; Gregory L. Blatch The co-chaperone murine stress-inducible protein 1 (mSTI1), an Hsp70/Hsp90 organizing protein (Hop) homologue, mediates the assembly of the Hsp70/Hsp90 chaperone heterocomplex. The mSTI1 protein can...
Journal Articles
J Cell Sci (2003) 116 (18): 3721–3728.
Published: 15 September 2003
... the proteins interacting with vFLIP in a KSHV-infected primary effusion lymphoma (PEL) cell line, we immunoprecipitated vFLIP and identified four associated proteins by mass spectrometry: IKK components IKKα, β and γ, and the chaperone, Hsp90. Using gel filtration chromatography, we demonstrated that a single...
Journal Articles
J Cell Sci (2002) 115 (14): 2809–2816.
Published: 15 July 2002
... function of signal transduction pathways. The relative levels of these proteins may be important, as too little or too much Hsp70 or Hsp90 can result in aberrant growth control, developmental malformations and cell death. Although the functions of heat shock proteins as molecular chaperones have been well...