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Keywords: Hrs
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Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2016) 129 (10): 2075–2084.
Published: 15 May 2016
... of Rb-mutant cells can potentially identify novel targets for therapeutic intervention in cancer. From a genetic screen in Drosophila , we identified synthetic lethal interactions between mutations of fly Rb ( rbf ) and the ESCRT-0 components stam and hrs . We show that inactivation of ESCRT-0...
Includes: Supplementary data
Journal Articles
In collection:
Membrane trafficking
J Cell Sci (2015) 128 (4): 755–767.
Published: 15 February 2015
... of ESCRT-0 at subpixel resolution and to perform particle-based colocalisation analysis with other endocytic markers. We demonstrate that although some of the ESCRT-0 subunit Hrs (also known as HGS) colocalises with the vacuolar early endosome marker EEA1, most localises to a population of peripheral EEA1...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2006) 119 (22): 4689–4701.
Published: 15 November 2006
... protein of unknown function, as a new regulator of endosome-to-lysosome trafficking. Yeast two-hybrid screen and co-immunoprecipitation analysis reveal that GRIF1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs), an essential component of the endosomal sorting machinery...
Journal Articles
J Cell Sci (2005) 118 (19): 4437–4450.
Published: 1 October 2005
... to ubiquitinated proteins. Two other UIM-containing endocytic proteins, Hrs and Hbp, also interact with ubiquilin in a UIM-dependent manner, whereas epsin does not. Immunofluorescence analysis showed that endogenous Eps15 and Hrs, but not epsin, colocalize with green-fluorescent-protein-fused ubiquilin...
Journal Articles
J Cell Sci (2003) 116 (20): 4169–4179.
Published: 15 October 2003
...Sylvie Urbé; Martin Sachse; Paula E. Row; Christian Preisinger; Francis A. Barr; Ger Strous; Judith Klumperman; Michael J. Clague Hepatocyte growth factor regulated tyrosine kinase substrate (Hrs), a main component of the `bilayered' clathrin coat on sorting endosomes, was originally identified...
Journal Articles
J Cell Sci (2001) 114 (17): 3075–3081.
Published: 1 September 2001
... signalling output by providing a different combination of downstream effectors at endocytic compartments compared with the plasma membrane. Rab5, Hrs and Cbl, are three examples of proteins that can influence both tyrosine kinase receptor trafficking and signalling pathways. By operating at this intersection...
Journal Articles
J Cell Sci (2000) 113 (12): 2273–2284.
Published: 15 June 2000
... substrate (Hrs). Hrs specifically interacts with SNAP-25, but not SNAP-23/syndet. The association of Hrs and SNAP-25 is mediated via coiled-coil interactions. Using an Hrs-specific antibody, we have shown that Hrs is highly enriched in brain, where it codistributes with SNAP-25 in most brain regions...