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Keywords: Host defense
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Journal Articles
Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages
FreeKefei Yuan, Canhua Huang, John Fox, Donna Laturnus, Edward Carlson, Binjie Zhang, Qi Yin, Hongwei Gao, Min Wu
Journal:
Journal of Cell Science
J Cell Sci (2012) 125 (2): 507–515.
Published: 15 January 2012
... infection. The intracellular PAO1-GFP count decreased in rapamycin-treated MH-S cells, indicating that induction of autophagy can increase host defense against this pathogen. By contrast, the number of intracellular bacteria was increased by blocking autophagy with 3-MA or beclin-1 siRNA in MH-S cells...
Includes: Supplementary data
