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Keywords: Homologous recombination
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Journal Articles
J Cell Sci (2020) 133 (12): jcs240036.
Published: 22 June 2020
... radiation (IR). Here, we show that inhibition of homologous recombination repair (HRR) by RIF1 occurs in a dose-dependent manner and is controlled via DNA replication. RIF1 inhibits both DNA end resection and RAD51 accumulation after exposure to high doses of IR. Contrastingly, HRR inhibition by RIF1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (3): jcs233437.
Published: 12 February 2020
... stability during DNA replication and chromosome segregation. Depletion of USP9X leads to DNA double-strand breaks, some of which are triggered by replication fork collapse. Here, we identify USP9X as a novel regulator of homologous recombination (HR) DNA repair in human cells. By performing cellular HR...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (4): 717–727.
Published: 15 February 2015
...Thomas Kusch ABSTRACT Homologous recombination is required for reciprocal exchange between homologous chromosome arms during meiosis. Only select meiotic recombination events become chromosomal crossovers; the majority of recombination outcomes are noncrossovers. Growing evidence suggests...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (2): 317–330.
Published: 15 January 2015
... and enhances DSB repair. Using DR-GFP and EJ5-GFP reporter systems, we demonstrate that BRG1 facilitates homologous recombination repair rather than nonhomologous end-joining (NHEJ) repair. Moreover, the BRG1–RAD52 complex mediates the replacement of RPA with RAD51 on single-stranded DNA (ssDNA) to initiate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2983–2994.
Published: 1 July 2014
... instability. Checkpoint Genome instability Homologous recombination Replicative stress can be caused by a wide variety of situations, including tightly bound protein–DNA complexes, clashes of the replication machinery with other cellular processes (i.e. transcription), the presence of non...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (4): 763–772.
Published: 15 February 2014
... homologous recombination repair (HRR) proteins can access the DNA in eukaryotes during repair. However, it remains unresolved how RNF20 itself approaches the DNA in the presence of chromatin structure. Here, we identified the histone chaperone FACT as a key protein in the early steps of HRR. Depletion...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (21): 4850–4855.
Published: 1 November 2013
... and hSSB1, INTS6 relocates to the DNA damage sites. Moreover, the hSSB1–INTS complex regulates the accumulation of RAD51 and BRCA1 at DNA damage sites and the correlated homologous recombination. For baculovirus, DNA fragments containing INTS3, INTS6, hSSB1, INTS3N (aa 1–628) and INTS3C (aa 593–1042...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (24): 6049–6057.
Published: 15 December 2012
...Fan Zhang; Gregory Bick; Jung-Young Park; Paul R. Andreassen Summary The PALB2 protein is associated with breast cancer susceptibility and Fanconi anemia. Notably, PALB2 is also required for DNA repair by homologous recombination (HR). However, the mechanisms that regulate PALB2, and the functional...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (10): 2523–2532.
Published: 15 May 2012
... Encystation Excystation Meiosis Homologous recombination The divergent eukaryotic parasite Giardia intestinalis (syn. Giardia lamblia, Giardia duodenalis ) is a major cause of diarrheal disease throughout the world. Additionally, as a diplomonad, it is a member of one of the earliest-diverging...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (7): 1633–1643.
Published: 1 April 2012
...Julian E. Sale Cells must overcome replication blocks that might otherwise lead to genomic instability or cell death. Classical genetic experiments have identified a series of mechanisms that cells use to replicate damaged DNA: translesion synthesis, template switching and homologous recombination...
Journal Articles
J Cell Sci (2011) 124 (10): 1655–1663.
Published: 15 May 2011
...Duen-Wei Hsu; Rhian Kiely; C. Anne-Marie Couto; Hong-Yu Wang; Jessica J. R. Hudson; Christine Borer; Catherine J. Pears; Nicholas D. Lakin DNA double-strand breaks (DSBs) can be repaired by homologous recombination (HR) or non-homologous end joining (NHEJ). The mechanisms that govern whether a DSB...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (4): 501–513.
Published: 15 February 2011
... 2011. 2011 DSB repair Meiosis Crossover control Homologous recombination Meiosis is the specialised reductive division that generates haploid cells. During this process, a single round of replication is followed by two rounds of chromosome segregation: in the first division (meiosis I...
Journal Articles
J Cell Sci (2011) 124 (1): 68–81.
Published: 1 January 2011
..., USA § Present address: Henry Ford Health System, Department of Urology, One Ford Place, Detroit, MI 48202, USA ¶ Author for correspondence ( jcampisi@buckinstitute.org ) 23 8 2010 © 2011. 2011 Aging Cancer Cellular senescence DNA repair Homologous recombination...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (13): 2228–2237.
Published: 1 July 2010
... or their repair through homologous recombination but is required for crossover formation. However, RAD-51 foci in ife-2 mutants persist into inappropriately late stages of meiotic prophase at 25°C, similar to mutants defective in MSH-4/HIM-14 and MSH-5, which stabilize a critical intermediate in crossover...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (17): 3093–3103.
Published: 1 September 2009
... © The Company of Biologists Limited 2009 2009 Homologous recombination Fluorescence recovery after photobleaching RAD51 RecQ helicase Bloom helicase (BLM) is a 1417 amino acid 3′ to 5′ helicase whose mutation leads to an autosomal recessive disorder called Bloom syndrome (BS...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (2): 162–166.
Published: 15 January 2008
... the impact of homologous recombination (HR) on the velocity of DNA replication forks. We used three hamster cell lines defective in HR either by overexpression of a RAD51 dominant-negative form, or by a defect in the RAD51 paralogue XRCC2 or the breast tumor suppressor BRCA2 . Irrespectively of the type...
Includes: Supplementary data
Journal Articles
J Cell Sci (2001) 114 (20): 3591–3598.
Published: 15 October 2001
... in the DNA damage response ( Fig. 3 ). It might, by contrast, be reasonable to posit that the role of BRCA2 in control of the RAD51 recombinase, and through it in DNA repair by homologous recombination, constitutes a key function. This view will also probably prove simplistic if current circumstantial...