... review the roles of SETD2 in mammals, with a focus on the central nervous system, and summarise the consequences of pathogenic SETD2 variants in humans. Central nervous system Chromatin Histone methylation SETD2 Australian Research Council http://dx.doi.org/10.13039/501100000923...

... of DIPG, our results suggest a new model by which H3K27me2/3 facilitates NHEJ and the maintenance of genome stability. This article has an associated First Person interview with the first author of the paper . Histone methylation H3K27me3 H3K27M NHEJ FANCD2 Genome stability National...

... by overexpression of Trx H3K4 methylase in Drosophila . TrxG PcG Histone methylation Drosophila Academia Sinica 10.13039/501100001869 A myriad of epigenetic factors, defined initially in Drosophila as the Polycomb group (PcG) repressors and trithorax group (trxG) activators...

... with the transcription co-activator UXT and activate NF-κB target genes. EZH1 UXT Histone methylation Transcription regulation NF-κB signaling pathway National Basic Research Program of China 2012CB518700 National Natural Science Foundation of China 10.13039/501100001809 31470771...

... for rapid transcriptional activation or repression ( Bernstein et al., 2006 ). Histone methylation Polycomb Histone demethylase DNA damage Embryonic stem cells Differentiation Summary: KDM6-specific H3K27me3 demethylase activity is crucially involved in the DNA damage response...

... containing Cdt2). However, the factors involved in positive regulation of PrSet7 histone methylation remain undefined. Here, we present biochemical and genetic evidence for a previously undocumented interaction between Drosophila PrSet7 (dPrSet7) and DNA polymerase α in Drosophila . Depletion...

.... , Cui   K. , Roh   T. Y. , Schones   D. E. , Wang   Z. , Wei   G. , Chepelev   I. , Zhao   K. ( 2007 ). High-resolution profiling of histone methylations in the human genome.   Cell   129 , 823 – 837 . 10.1016/j.cell.2007.05.009 Baud   V. , Karin   M. ( 2009...

... Heterochromatin Histone methylation Advances in histone modification mapping have revealed that different histone signatures are associated with various chromatin states. In accordance with a loosely defined histone code, prevalent combinations of modifications have been found to demarcate...

... 11 2008 © The Company of Biologists Limited 2009 2009 Chromatin Heterochromatin Histone methylation HP1 Nuclear organisation Transcriptional repression Zinc-finger proteins (ZFPs) that contain the Krüppel-associated box (KRAB) domain comprise the largest single family...

...-mail: [email protected] ) 17 11 2008 © The Company of Biologists Limited 2009 2009 Arginine methylation Subcellular localization and dynamics Posttranslational modification Histone methylation Epigenetics Post-translational modification of proteins is an important means...

... of lysine 4 of histone H3 indicates activation. Histone lysines can be mono-, di- or trimethylated ( Lachner et al., 2003 ). Post-meiotic germ cells of Drosophila are virtually completely transcriptionally silent (for a review, see Renkawitz-Pohl et al., 2005 ); thus, histone methylation on lysine...

... and Ruiz, 2002 ). We here investigated histone methylation modifications between chromosomes in germline cells of Sciara ocellaris . In early germ nuclei, maternal chromosomes show high levels of di- and trimethylated histone H3 at Lys4, whereas this histone modification is not detected in paternal...

... Cell cycle Transcription repression Histone acetylation Histone methylation The retinoblastoma tumor suppressor protein (pRB) and its relatives, p107 and p130, are negative regulators of cell proliferation that figure prominently in most models of cell-cycle control. Cell-cycle progression...