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Keywords: Heterotrimeric G-proteinsClose
J Cell Sci (2008) 121 (2): 234–245.
Published: 15 January 2008
..., making use of totipotent mouse F9 teratocarcinoma cells that respond to WNT3a via Frizzled-1. The canonical WNT–β-catenin signaling pathway requires both Gα o and Gα q heterotrimeric G-proteins, whereas we show that WNT-JNK signaling requires only Gα o protein. Gα o propagates the signal downstream...
Includes: Supplementary data
J Cell Sci (2007) 120 (19): 3404–3414.
Published: 01 October 2007
...Michael E. Feigin; Craig C. Malbon The Wnt–β-catenin pathway controls numerous cellular processes, including differentiation, cell-fate decisions and dorsal-ventral polarity in the developing embryo. Heterotrimeric G-proteins are essential for Wnt signaling, and regulator of G-protein signaling...
J Cell Sci (2004) 117 (25): 5995–6005.
Published: 01 December 2004
... formation of inositol trisphosphate. However, the upstream activators or modulators of this signaling pathway are not known. We recently identified four Gα subunits of heterotrimeric G-proteins present in the sea urchin egg, and here we find that activation of G-proteins of the Gα s and Gα q type, but not...