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Keywords: Heterochromatin
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Journal Articles
J Cell Sci (2023) 136 (19): jcs261092.
Published: 11 October 2023
... into constitutive heterochromatin, which protect genome integrity and cell identity. De novo formation of heterochromatin during preimplantation development is an essential step for preserving the ground-state of pluripotency and the self-renewal capacity of embryonic stem cells (ESCs). However, the molecular...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (11): jcs258932.
Published: 8 June 2022
... on cell proliferation. In contrast, Ki-67 is important for localising nucleolar material to the mitotic chromosome periphery and for structuring perinucleolar heterochromatin, and emerging data indicate that it also has critical roles in cancer development. However, its mechanisms of action have not yet...
Includes: Supplementary data
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J Cell Sci (2021) 134 (12): jcs251264.
Published: 21 June 2021
... heterochromatin environment and regulating expression of VSG genes ( DuBois et al., 2012 ; Maishman et al., 2016 ), which normally organized into heterochromatin when in a quiescent state ( Figuereido and Cross, 2010 ). Importantly, there was a normal retention of heterochromatin observed as electron-dense...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (3): jcs257717.
Published: 1 February 2021
... compaction. We find that its depletion induces a decompaction of pericentromeric heterochromatin, which is similar to what is observed upon the knockdown of HP1β (also known as CBX1), a key factor of the heterochromatin structure. We show that PA28γ is present at HP1β-containing repetitive DNA sequences...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs247643.
Published: 27 January 2021
... and prevents maturation towards the hypertrophic state. Mechanistically, hydrostatic pressure reduces the amount of trimethylated H3K9 (K3K9me3)-marked constitutive heterochromatin and concomitantly increases H3K27me3-marked facultative heterochromatin. Reduced levels of H3K9me3 attenuates expression of pre...
Includes: Supplementary data
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J Cell Sci (2017) 130 (14): 2416–2429.
Published: 15 July 2017
... show here that the parthenotes/zygotes derived from enucleolated oocytes exhibited abnormal heterochromatin formation around parental pericentromeric DNAs, which led to a significant mitotic delay and frequent chromosome mis-segregation upon the first mitotic division. A proteomic analysis identified...
Includes: Supplementary data
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J Cell Sci (2017) 130 (2): 480–489.
Published: 15 January 2017
... in the regulation of chromatin structure in the ciliated protozoan Tetrahymena thermophila . Jub6p forms sodium dodecyl sulfate (SDS)-resistant aggregates when it is ectopically expressed in vegetative cells and binds to RNA in vitro . Jub6p is a heterochromatin component and is important for the formation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (5): 1046–1058.
Published: 1 March 2016
... Ltd 2016 Summary: Long double-stranded RNAs are differentially expressed and distributed during nuclear differentiation to affect small RNA production and DNA rearrangements in Tetrahymena . Ciliates Genome rearrangements dsRNA RNAi Heterochromatin With the capacity to carry...
Includes: Supplementary data
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J Cell Sci (2011) 124 (18): 3149–3163.
Published: 15 September 2011
... heterochromatinization, resulting in cell cycle arrest. Taken together, our data demonstrate the role of a novel heterochromatin-associated protein in transcriptional repression. References Abhiman S. , Iyer L. M. , Aravind L. ( 2008 ). BEN: a novel domain in chromatin factors and DNA viral...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (12): 2041–2048.
Published: 15 June 2011
... regulated by the histone deacetylase Rpd3. * Authors for correspondence ( giovanni.cenci@cc.univaq.it ; dcorona@unipa.it ) 2 3 2011 © 2011. 2011 Telomere Rpd3 Heterochromatin Histone acetylation Histone H3K9 trimethylation HP2 Eukaryotic linear chromosomes have evolved...
Includes: Supplementary data
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J Cell Sci (2010) 123 (16): 2853–2861.
Published: 15 August 2010
...-1 p180, the largest subunit of Drosophila CAF-1, participates in the process of heterochromatin formation and functions to maintain pericentric heterochromatin stability. We provide evidence that Drosophila CAF-1 p180 plays a role in both classes of position effect variegation (PEV...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2697–2707.
Published: 15 August 2010
..., the degenerating muscles in mute mutants show aberrant localisation of heterochromatin protein 1 (HP1). We further show a genetic interaction between mute and the Stem-loop binding protein ( Slbp ) and a loss of muscle striations in Lsm11 mutants. These data demonstrate a novel role of HLB components and histone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (13): 2207–2217.
Published: 1 July 2010
... that is distinct from its known functions in genetic processes. * Author for correspondence ( gerlitzg@mail.nih.gov ) 31 3 2010 © 2010. 2010 Cell migration Chromatin Heterochromatin HMGs Histone H1 Proper cell migration has a key role in the correct progression of numerous...
Includes: Multimedia, Supplementary data