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Keywords: Heterochromatin
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Journal Articles
J Cell Sci (2021) 134 (12): jcs251264.
Published: 21 June 2021
... Heterochromatin The nucleus is delineated by a double lipid membrane bilayer, the nuclear envelope (NE), and is supported by a proteinaceous lamina that influences nuclear shape, size and resilience to physical forces together with mechano-signalling capability ( Gruenbam and Foisner, 2015 ; Swift...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (3): jcs257717.
Published: 01 February 2021
... compaction. We find that its depletion induces a decompaction of pericentromeric heterochromatin, which is similar to what is observed upon the knockdown of HP1β (also known as CBX1), a key factor of the heterochromatin structure. We show that PA28γ is present at HP1β-containing repetitive DNA sequences...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs247643.
Published: 27 January 2021
... and prevents maturation towards the hypertrophic state. Mechanistically, hydrostatic pressure reduces the amount of trimethylated H3K9 (K3K9me3)-marked constitutive heterochromatin and concomitantly increases H3K27me3-marked facultative heterochromatin. Reduced levels of H3K9me3 attenuates expression of pre...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (14): jcs242610.
Published: 24 July 2020
... regions. Paradoxically, heterochromatin can also antagonize de novo centromere formation, and some centromeres lack it altogether. In order to investigate the importance of heterochromatin at centromeres, we used epigenetic engineering of a synthetic alphoid tetO human artificial chromosome (HAC...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs240416.
Published: 27 May 2020
...Kelly L. Dunlevy; Valentina Medvedeva; Jade E. Wilson; Mohammed Hoque; Trinity Pellegrin; Adam Maynard; Madison M. Kremp; Jason S. Wasserman; Andrey Poleshko; Richard A. Katz ABSTRACT A large fraction of epigenetically silent heterochromatin is anchored to the nuclear periphery via ‘tethering...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (14): 2416–2429.
Published: 15 July 2017
... show here that the parthenotes/zygotes derived from enucleolated oocytes exhibited abnormal heterochromatin formation around parental pericentromeric DNAs, which led to a significant mitotic delay and frequent chromosome mis-segregation upon the first mitotic division. A proteomic analysis identified...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (9): 1570–1582.
Published: 01 May 2017
... reprogramming have suggested that the group of macroH2A histone variants might function through stabilizing the differentiated state by a yet unknown mechanism. Here, we present results demonstrating that macroH2A variants have a major function in maintaining nuclear organization and heterochromatin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (3): 590–601.
Published: 01 February 2017
... organisation in interphase nuclei of the model plant Arabidopsis thaliana in which heterochromatin clusters in conspicuous chromatin domains called chromocentres. Chromocentres form a repressive chromatin environment contributing to transcriptional silencing of repeated sequences, a general mechanism needed...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (2): 480–489.
Published: 15 January 2017
... in the regulation of chromatin structure in the ciliated protozoan Tetrahymena thermophila . Jub6p forms sodium dodecyl sulfate (SDS)-resistant aggregates when it is ectopically expressed in vegetative cells and binds to RNA in vitro . Jub6p is a heterochromatin component and is important for the formation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (5): 1046–1058.
Published: 01 March 2016
..., and these interactions could most efficiently be mediated through non-coding RNAs with their rich and specific sequence information. Two proteins (Drb1p and Drb2p) with specific dsRNA-binding motifs (DSRMs) have been shown to localize to the heterochromatin region and DRB2 is required for DNA deletion. They could...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (15): 3347–3359.
Published: 01 August 2014
... is controlled at pericentric heterochromatin (PHC). Whereas in euchromatin newly synthesized H2A and H2A.Z are deposited throughout the cell cycle, we reveal two discrete waves of deposition at PHC – during mid to late S phase in a replication-dependent manner for H2A and during G1 phase for H2A.Z. This G1 cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (24): 4309–4317.
Published: 15 December 2011
... interaction assays with strong JIL-1 hypomorphic loss-of-function alleles have demonstrated that the JIL-1 protein can counterbalance the effect of the major heterochromatin components on position-effect variegation (PEV) and gene silencing. However, it is unclear whether this was a causative effect...
Journal Articles
J Cell Sci (2011) 124 (18): 3149–3163.
Published: 15 September 2011
... heterochromatinization, resulting in cell cycle arrest. Taken together, our data demonstrate the role of a novel heterochromatin-associated protein in transcriptional repression. * Author for correspondence ( supriyap@life.illinois.edu ) 2 6 2011 © 2011. 2011 BEND3 Heterochromatin...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (12): 2041–2048.
Published: 15 June 2011
... regulated by the histone deacetylase Rpd3. * Authors for correspondence ( giovanni.cenci@cc.univaq.it ; dcorona@unipa.it ) 2 3 2011 © 2011. 2011 Telomere Rpd3 Heterochromatin Histone acetylation Histone H3K9 trimethylation HP2 Eukaryotic linear chromosomes have evolved...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (11): 1878–1890.
Published: 01 June 2011
...Tuempong Wongtawan; Jane E. Taylor; Kirstie A. Lawson; Ian Wilmut; Sari Pennings We report here that the formation of heterochromatin in cell nuclei during mouse development is characterised by dynamic changes in the epigenetic modifications of histones. Our observations reveal that heterochromatin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2697–2707.
Published: 15 August 2010
..., the degenerating muscles in mute mutants show aberrant localisation of heterochromatin protein 1 (HP1). We further show a genetic interaction between mute and the Stem-loop binding protein ( Slbp ) and a loss of muscle striations in Lsm11 mutants. These data demonstrate a novel role of HLB components and histone...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (16): 2853–2861.
Published: 15 August 2010
...-1 p180, the largest subunit of Drosophila CAF-1, participates in the process of heterochromatin formation and functions to maintain pericentric heterochromatin stability. We provide evidence that Drosophila CAF-1 p180 plays a role in both classes of position effect variegation (PEV...
Includes: Supplementary data
Journal Articles
J Cell Sci (2010) 123 (13): 2207–2217.
Published: 01 July 2010
..., National Cancer Institute. Deposited in PMC for release after 12 months. References Agarwal N. , Hardt T. , Brero A. , Nowak D. , Rothbauer U. , Becker A. , Leonhardt H. , Cardoso M. C. ( 2007 ). MeCP2 interacts with HP1 and modulates its heterochromatin...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (7): 937–946.
Published: 01 April 2009
... and repressed reporter target genes to domains of constitutive heterochromatin in the nucleus. However, we show here that although KAP1 does indeed become recruited to pericentric heterochromatin during differentiation of mouse embryonic stem (ES) cells, endogenous KRAB-ZFPs do not. Rather, KRAB-ZFPs and KAP1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (21): 3608–3618.
Published: 01 November 2008
... to the lysosome via retrograde membrane trafficking. Nuclear envelope localization of proAR involves truncation of the C-terminus, which subsequently activates the ER-retrieval signal. The truncated form of proAR interacts with A-type lamin and is retained at the inner nuclear membrane. Heterochromatin formation...
Includes: Supplementary data