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Keywords: Her2
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Journal Articles
J Cell Sci (2023) 136 (7): jcs260133.
Published: 27 March 2023
... factors may define context-specific control of EGFR signaling. Ligand-bound EGFR can homodimerize or instead undergo heterodimerization with the related receptor HER2 (also known as ERBB2) when the latter is expressed. We examined how EGFR signaling in the presence of HER2 distinctly requires flotillin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (21): 3961–3976.
Published: 1 November 2015
... of cell cycle exit, through the engagement of the CDK inhibitor CDKN1A. Only in proliferating cells can HDAC7 bind to the first intron of the CDKN1A gene, a region characterized by epigenetic markers of active promoters and enhancers. In cells transformed by the oncogene HER2 (ERBB2), acini morphogenesis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (12): 2340–2350.
Published: 15 June 2015
..., whereas its overexpression promoted neuronal differentiation, suggesting an essential role of mecp2 in directing neural precursors into differentiated neurons. Mechanistically, her2 (the zebrafish ortholog of mammalian Hes5 ) was upregulated in mecp2 morphants in an Id1-dependent manner. Moreover...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2009) 122 (20): 3780–3790.
Published: 15 October 2009
... of tyrosine phosphorylation in emerin. We validated one study, confirming that emerin is hyper-tyrosine-phosphorylated in Her2-overexpressing cells. We discovered that non-receptor tyrosine kinases Src and Abl each phosphorylate emerin and a related protein, LAP2β, directly. Src phosphorylated emerin...
Journal Articles
J Cell Sci (2008) 121 (19): 3155–3166.
Published: 1 October 2008
... kinase Receptor downregulation Arf6 Rho-family GTPase HER2 ErbB2 is a member of the ErbB family of receptor tyrosine kinases, which also includes the epidermal growth factor receptor (EGFR or ErbB1) ( Yarden and Sliwkowski, 2001 ). ErbB2 is the preferred heterodimerization partner...
Includes: Supplementary data