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1-16 of 16
Keywords: Heparan sulfate
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Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2022) 135 (6): jcs259297.
Published: 17 March 2022
...Yulu Cherry Liu; Bradley M. Wierbowski; Adrian Salic ABSTRACT Glypicans are a family of cell surface heparan sulfate proteoglycans that play critical roles in multiple cell signaling pathways. Glypicans consist of a globular core, an unstructured stalk modified with sulfated glycosaminoglycan...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2018) 131 (10): jcs210781.
Published: 29 May 2018
...Meina Huang; Hua He; Tatyana Belenkaya; Xinhua Lin ABSTRACT Heparan sulfate proteoglycans (HSPGs) have been shown to regulate various developmental processes. However, the function of heparan sulfate (HS) during the development of mammalian stomach has not been characterized yet. Here, we...
Includes: Supplementary data
Journal Articles
Yu-Ja Huang, Paula Schiapparelli, Kristen Kozielski, Jordan Green, Emily Lavell, Hugo Guerrero-Cazares, Alfredo Quinones-Hinojosa, Peter Searson
Journal:
Journal of Cell Science
J Cell Sci (2017) 130 (15): 2459–2467.
Published: 1 August 2017
... the importance of galvanotaxis in development and disease, the mechanism by which cells sense and migrate directionally in an electric field remains unknown. Here, we show that electrophoresis of cell surface heparan sulfate (HS) critically regulates this process. HS was found to be localized at the anode-facing...
Includes: Supplementary data
Journal Articles
Corinna Ortmann, Ute Pickhinke, Sebastian Exner, Stefanie Ohlig, Roger Lawrence, Hamodah Jboor, Rita Dreier, Kay Grobe
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (12): 2374–2385.
Published: 15 June 2015
... heparan sulfate proteoglycans regulate this process, through their heparan sulfate chains, in a cell autonomous manner. Heparan sulfate specifically modifies Shh processing at the cell surface, and purified glycosaminoglycans enhance the proteolytic removal of N- and C-terminal Shh peptides under cell...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2015) 128 (7): 1408–1421.
Published: 1 April 2015
... is the heparan-sulfate-specific 6-O-endosulfatase Sulf1. Sulf1 acts extracellularly to modify the structure of heparan sulfate chains to affect the bio-availability of Wnt ligands. Sulf1 could, therefore, influence the formation of Wnt signalling complexes to modulate the activation of both canonical and non...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2009) 122 (24): 4492–4504.
Published: 15 December 2009
... motoneurons with midline guidepost function. Curr. Biol. 16 , 1871 -1883. Bülow, H. E. and Hobert, O. ( 2004 ). Differential sulfations and epimerization define heparan sulfate specificity in nervous system development. Neuron 41 , 723 -736. Bülow, H. E. and Hobert, O. ( 2006...
Includes: Supplementary data
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (15): 3189–3199.
Published: 1 July 2004
... macropinocytic pathway. A substantial body of literature suggests that full activity of FGFs requires not only receptor interactions but also their internalization ( Goldfarb, 2001 ) and that the latter may proceed via heparan sulfate proteoglycans-dependent and -independent pathways ( Citores et al., 1999...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (15): 3331–3341.
Published: 1 July 2004
...Naoko Nagai; Hiroko Habuchi; Jeffrey D. Esko; Koji Kimata Heparan sulfate O -sulfotransferases catalyze the O -sulfation of the glucosamine and uronic acid residues of heparan sulfate, thereby determining the binding sites for ligands necessary for important biological functions...
Journal Articles
Juan Carlos Casar, Claudio Cabello-Verrugio, Hugo Olguin, Rebeca Aldunate, Nibaldo C. Inestrosa, Enrique Brandan
Journal:
Journal of Cell Science
J Cell Sci (2004) 117 (1): 73–84.
Published: 1 January 2004
... binding growth factors such as FGFs, HGF and TGFβ. Heparan sulfate proteoglycans, key components of cell-surfaces and ECM, modulate growth factor activities and influence cell growth and differentiation. Their expression in forming muscle masses during development and in cell culture, suggest...
Journal Articles
Guido J. Jenniskens, Maria Ringvall, Werner J. H. Koopman, Johan Ledin, Lena Kjellén, Peter H. G. M. Willems, Erik Forsberg, Jacques H. Veerkamp, Toin H. van Kuppevelt
Journal:
Journal of Cell Science
J Cell Sci (2003) 116 (11): 2187–2193.
Published: 1 June 2003
...Guido J. Jenniskens; Maria Ringvall; Werner J. H. Koopman; Johan Ledin; Lena Kjellén; Peter H. G. M. Willems; Erik Forsberg; Jacques H. Veerkamp; Toin H. van Kuppevelt The biosynthesis of heparan sulfate, present on the cell surface and in the basal lamina surrounding cells, is a multistep process...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2002) 115 (9): 1951–1959.
Published: 1 May 2002
...Jian Li; Nicholas W. Shworak; Michael Simons Binding of basic fibroblast growth factor (FGF2) to its high affinity receptors requires the presence of specific heparan sulfate (HS) moieties on the cell surface that act as coreceptors. To determine the contribution of cell-surface HS to modulation...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (2001) 114 (9): 1613–1623.
Published: 1 May 2001
...Thomas P. Richardson; Vickery Trinkaus-Randall; Matthew A. Nugent ABSTRACT Heparan sulfate proteoglycans (HSPG) regulate multiple cellular processes and mediate the cellular uptake of numerous molecules. While heparan sulphate glycosaminoglycan chains are known to modulate receptor binding...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1999) 112 (20): 3415–3420.
Published: 15 October 1999
...John R. Couchman; Anne Woods ABSTRACT It is now becoming clear that additional transmembrane components can modify integrin-mediated adhesion. Syndecan-4 is a transmembrane heparan sulfate proteoglycan whose external glycosaminoglycan chains can bind extracellular matrix ligands and whose core...
Journal Articles
Nadia Soussi-Yanicostas, Catherine Faivre-Sarrailh, Jean-Pierre Hardelin, Jacqueline Levilliers, Geneviève Rougon, Christine Petit
Journal:
Journal of Cell Science
J Cell Sci (1998) 111 (19): 2953–2965.
Published: 10 January 1998
... on the presence of heparan sulfate and chondroitin sulfate glycosaminoglycans at the cell surface. A major cell adhesion site of anosmin-1 was identified in a 32 amino acid (32R1) sequence located within the first fibronectin-like type III repeat of the protein. The role of anosmin-1 as a substrate for neurite...
Journal Articles
Journal:
Journal of Cell Science
J Cell Sci (1994) 107 (11): 2975–2982.
Published: 1 November 1994
... group of cell surface proteoglycans, the members of the syndecan gene family. * Author for correspondence © 1994 by Company of Biologists 1994 angiogenesis extracellular matrix fibroblast growth factor heparan sulfate tumorigenesis Cell surface proteoglycans are membrane...
Journal Articles
Laina Karthikeyan, Manuela Flad, Margit Engel, Birgit Meyer-Puttlitz, Richard U. Margolis, Renée K. Margolis
Journal:
Journal of Cell Science
J Cell Sci (1994) 107 (11): 3213–3222.
Published: 1 November 1994
... of synthesis of glypican, a glycosylphosphatidylinositol-anchored heparan sulfate proteoglycan. Glypican immunoreactivity is present in the marginal layer (prospective white matter) and in the dorsal root entry zone of E13-16 spinal cord, as well as in the optic nerve and retina at this stage, but does...