... Hemidesmosomes Keratinocytes Plectin Transepidermal water loss Plectin, a highly versatile cytolinker protein, is essential in maintaining the integrity of skin, muscle and heart cytoarchitecture. It is expressed in a wide variety of mammalian cells and tissues and plays an important role in mediating...

... at the plasma membrane. The results suggest that maintenance of desmosomes and hemidesmosomes may require some tension, normally mediated by keratin attachments. Flexplates (Flexcell International, USA) were coated with collagen (Sigma) for 60 minutes at room temperature and then incubated for 60 minutes...

..., which have features of both adherens and tight junctions; (2) dense bodies, which are muscle-attachment structures similar to focal adhesions; (3) fibrous organelles, which resemble hemidesmosomes and mediate mechanical coupling between tissues; and (4) a putative dystrophin-glycoprotein complex...

...Annette M. Gonzalez; Carol Otey; Magnus Edlund; Jonathan C. R. Jones Hemidesmosomes are multimeric protein complexes that attach epithelial cells to their underlying matrix and serve as cell surface anchorage sites for the keratin cytoskeleton. Two hemidesmosome components, the α6β4 integrin...